ID J3K946_COCIM Unreviewed; 1427 AA.
AC J3K946;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Membrane-tethered transcription factor {ECO:0000313|EMBL:EAS31394.3};
GN ORFNames=CIMG_06873 {ECO:0000313|EMBL:EAS31394.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS31394.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704912; EAS31394.3; -; Genomic_DNA.
DR RefSeq; XP_001242977.1; XM_001242976.2.
DR STRING; 246410.J3K946; -.
DR GeneID; 4561165; -.
DR KEGG; cim:CIMG_06873; -.
DR VEuPathDB; FungiDB:CIMG_06873; -.
DR InParanoid; J3K946; -.
DR OMA; HPMMRRI; -.
DR OrthoDB; 2901153at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00102; IPT; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR PANTHER; PTHR24171; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED; 1.
DR PANTHER; PTHR24171:SF9; L-ASPARAGINASE; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1379..1399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 818..887
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|Pfam:PF01833"
FT REPEAT 1003..1035
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1036..1068
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 76..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1124..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..654
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1427 AA; 155327 MW; FC54E82787FDE97C CRC64;
MPPVNVSASP KFAGCEPFIV DSDMGSLDEE GDLRCFDPSV LEVSGPNTVH DFEDLFIRPS
SSAQMSDAMS CMSDLTSKAT THRHPPAAES RLSPSDSRSE SPGESSNGSS ANSPLGHTRN
LSLFSNPSEA FSPGSVGTDQ FLPTWPNSHD YSLAEESFVA QDGRSLSVKE EYATETDIEM
SNKAMDSAFD FESAASSPSP LASRAASEKR NTDLSKEALN TSNLAKVESS QNPSYPVQNV
SPLIFQRTAD LYSTFPKSTN GLKFWNNTSS PDLDGGLGAI AMNGTSPLHA TLAPSLNFKS
YPSPFESTPY HPAVVFPMSD ANAMFHPSFG FENYIPPRLI VHPTALKSRV ETQIPIKLTL
YPMPSGVKKL RLPTYTISKP KFFAKPDTPR SPDVFELSVS LVCTSAMQDK KKRERAFARA
RGEQLPSQSS MREDGSEDSQ EEDNTPLKGG EVKICAGCIQ RERKRASRKK QKKPEEDELF
QKEEDKRVIV FNTTEMKDWV DPPRITSSSG AEASTPPAPL GSMQVELPMR IACYCRHQGE
KMGFQVIFTI KDYLGNLIAQ EMTNSIMITD DHKTHTPSNQ TSASSTPPEN PVANARLFPS
NAPVDMGKQF IHQAPFKLSH SATDLQALRK QQHPLTPGNF SQSQSPSGTS GVAAPRGVSR
QAPSRDLPGP LAKRRKQNSP GKIPSGLAMT KVESASNSAT QKPKQAATGP SSQATPPQME
QPFVMPSSMV TQFGNGPPTP ITTDSNFFSP RDRPQTLENL PQQSLLSAPS SAHPSRPGTP
GSSSRNAATE QVVNGASNPA TQTPIWNIPP NLPQQMPPMI HKLVPAEGST TGGSEVTLLG
SGFYPGMEVV FGDTLATTTT FWGDKCLNCL TPPALQPGTV PVVFKHEHPR FGQVQQTPPI
IPKQQTFFRY VDDRELQMYR VALGILGQKL RNPADAYRTA QQIMGGDPNT LWNIQNGFQS
GQQRGGSNNC NMTELDAKML VYLEFMDLDD TPGAPKFNMR SPAGQTLLHF AASLGLTRFA
AGLLARGANP DVQDNNGNTP LHLAAISGHT HIVHRLRLSG ANVAARNLRD FTSADLASSL
EVHQAVLIPS RHYRSRSVGS TPSLRRRLSS GSLNDFWESA SSDEAGEIST DLSESSDDAV
ESNNDNADSP FYQPVSRRQS AVLQNQPGYF MAGPSESILQ TSEAVTAGET EGNVAGRGFS
PPAALVAWRD QLATQINQFQ QSVNRAFPNL PALPPMPTLP GLPDYQAYPM IQRISSLVPH
RPATSWSTNL MKDGWDRLTG NSSPPAYDEL YPVKEASEDQ EVKKSSIVEA ALDAAVDQHF
EAQLKASSSS SSSSSTATEV KEDIGDVRIG RKAISRQQQE QLRKAHALKM KRIRSDRNLF
FIWIPLLIIV IFAMLQNIFP SFWQGASQGY HFLKTRYATG RVEAIPT
//
