ID J3KG56_COCIM Unreviewed; 402 AA.
AC J3KG56;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Methionine synthase {ECO:0000313|EMBL:EAS34691.3};
GN ORFNames=CIMG_00045 {ECO:0000313|EMBL:EAS34691.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS34691.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704911; EAS34691.3; -; Genomic_DNA.
DR RefSeq; XP_001246274.2; XM_001246273.2.
DR AlphaFoldDB; J3KG56; -.
DR STRING; 246410.J3KG56; -.
DR GeneID; 4565889; -.
DR KEGG; cim:CIMG_00045; -.
DR VEuPathDB; FungiDB:CIMG_00045; -.
DR InParanoid; J3KG56; -.
DR OMA; HPMLDHF; -.
DR OrthoDB; 5488137at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR CDD; cd03311; CIMS_C_terminal_like; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR002629; Met_Synth_C/arc.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR PANTHER; PTHR43844; METHIONINE SYNTHASE; 1.
DR PANTHER; PTHR43844:SF2; SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED; 1.
DR Pfam; PF01717; Meth_synt_2; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 179..377
FT /note="Cobalamin-independent methionine synthase MetE C-
FT terminal/archaeal"
FT /evidence="ECO:0000259|Pfam:PF01717"
SQ SEQUENCE 402 AA; 45364 MW; 8A466919286C66BE CRC64;
MDVKASRNPP FRAEHLGSLL RTDELLQKRA AVDKGTASAA ELEPLEDRDI REIVDLQRKL
GFHGITDGEY RRHMFWGSFW PGLEGMTELK NPEPETFRPY LPDVAAFTEK GYRPGESVIC
TGKIKHVGST YLKELDYLKS LVPADDVKSL KLTLPAPNWY HLRYKEGRAY PKHVYPSDDE
FFADVAKAYQ TELQLLYDAG LRNVQIDDPN LAYFCSESML AGWKADPLNK GSADELLDAY
IELYNDCLSK RPADMHVGLH ICRGNFVNSR HFSEGGYDRI ATRLFKKLNV DTYYLEYDTP
RAGGFEPLVH VPKGKNVIVG VITSKFPELE EEAEMRRRVL KAAEFMARGS GESVEEALDR
LGLSPQCGFA SHSSGNAVDR GDMVNKLKLV RRVADSLWPG QP
//
