ID J3KII0_COCIM Unreviewed; 2609 AA.
AC J3KII0;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=HEAT repeat protein {ECO:0000313|EMBL:EAS35778.3};
GN ORFNames=CIMG_01132 {ECO:0000313|EMBL:EAS35778.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS35778.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704911; EAS35778.3; -; Genomic_DNA.
DR RefSeq; XP_001247361.1; XM_001247360.1.
DR STRING; 246410.J3KII0; -.
DR GeneID; 4566942; -.
DR KEGG; cim:CIMG_01132; -.
DR VEuPathDB; FungiDB:CIMG_01132; -.
DR InParanoid; J3KII0; -.
DR OMA; EGLMAMF; -.
DR OrthoDB; 5482709at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR046523; UTP20_C.
DR InterPro; IPR011430; UTP20_N.
DR PANTHER; PTHR17695:SF11; SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG; 1.
DR PANTHER; PTHR17695; UNCHARACTERIZED; 1.
DR Pfam; PF20416; UTP20_C; 1.
DR Pfam; PF07539; UTP20_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 875..1486
FT /note="U3 small nucleolar RNA-associated protein 20 N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF07539"
FT DOMAIN 1689..1907
FT /note="U3 small nucleolar RNA-associated protein 20 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF20416"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2573..2609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2609 AA; 293707 MW; F53BA57DBE0BF9A3 CRC64;
MAGAHSARGK PPKLRKGGTE TTKSHRFEPF SQRIAKLKID PVHRVRRNSF SEENGDESCS
YFRASLEHWM ELNLSENFTE FSQRAGRLCE SLPQVLYHQD AIMDLLAEYI RRRDELSMEP
LLSLMAQFAR DLGSRFEKHF ATTVRLVASV AATHSSIEVI EWSFTCLAWI FKFLSRLLVP
DLRQLLGIMS PYLGKQPQKH FVARFAAESM SFLIRKAALV YYKNKAPLER AVTFIFEDLS
KTEGQRQIAM YQEGLMNMFA DAVKGVKGGI HSNGADILQC LMTSATMEDA THSAVAEAVL
SGVLINLVHY CTSDTFSPVL DVICDYIEAS SKKSSAIHFR VNVHLLFLAV VTRKGSRIQG
WKRVHKVLLC LFKEAAGNSE LNTLSIEQLS GATAIAIQTS PMDELLPHMR QIMEIIIRDP
LSQYFLPFCL FLSSFGSDRF YSVVLPYFQR FIVSLWQDYE AGFCLTLPRL RSLNCVTAQA
NRSGYLTCPN GWKEHIARQF SNKKPTTRDI TFLYAYTTLQ GALSFSTPPS IVPQILESLH
HLLLTSANPQ SNRKVDLDSF ACGQGFLAYV QLAAQMKELD SNVWDLVISR GVEFATVPVF
LEATLGFMTA SNKPPQFSGE KIEPFVDTLL SILAGPSHEL RLSSLKIIQA VLCWLDVETV
CISTAIEIEQ SDLTLQTARE LSMLVRRLAS SYAEASKLKW LDRLIPNFCF GLLSKKLASL
WDDTCEAIKV ICEDSTGERT VTDLAMSWLQ EGSSSGSDET NEADANEENS IVTSEFQCFN
VLNVEKSLML SFEAARDSES LLVDDFKNAH KPVVLTPVYA RSQALRVLSA VPHVAEKRSR
QLVPLFLSWT SKDDEPLNSS SGSSSTLAMD ETKARWDLRD KKAMLTLLGK FTNPKVLYKA
SEVHDTLANL LCNGDSEIQK LAMKAIFTWK SPAVQPYEQN LLNLLDDARF RDELAVFVHL
GKDNSIIEDE HREGLFPYLL RLLYGKMVAR SGLRGSQGGG QEGRRKAILR AISQLSEKDF
EHFIRIAFGP LANVNILDGV SEHQSVLAQE VLGPRKQYGL LKMIETMFST LKSRMHAYVD
CTMNVILYCI VRACRQLHAG DEIREEDSNQ NSQLSLLRNV RQIGTRCLEL VFSVSSDVDW
TPYMPIIFAE VINPRLPNFA VETAQSISGL LQLFRTWASH PKSTLYLCNS NVVPKVVNIL
GVESAREGVK LFVLDEVLTP LVNAATCPEK DKDGDADIET MSLVRTGVFA SHVEYMLVQI
DSLLRKQSSR QLTLSGVEIL SKLAQFVESS TETSKLIDTT IYLLQQPPDR VPPRTKGGLL
RVLQQFLPLY NPEGNDELSG QLFEVLSSMF DYFKDDANRE ALSKVFELFS KRRPELIEVS
RLAADLNSLS SKRLDEVDFE RRLGAFHAIN EEKFSTFSAR QWRPLLYNLL YHIKDEEELA
IRSSASLGIR RFIKCAAPSE EIEIPEFREL VDKVLLPSLK SGVKQNAETV RAEFVAVLGY
LIQLHPKHPN LSDLYDLLAN GDEEASFFNN ILHIQQHRRQ RALRRLTTEV TKGKISASNI
STVFFPLIEH YVFNQAEDDN AHNLAAEAVS TIGILAGGLE WNQFRAIFRR FKDYLRSKPG
MEKNIIRLLG QLTDALTRAS NSTPSATEEI SVDGIAKSTL SRSLPSLAQV ASELKSHFIP
FLSKFIHHKE ESEVSLRLPV AVTTVKLLKL LPEEERALLL PPVLLDISNI LKSKSQDSRD
VARKTLADIA LILGPSYFGY ILKELRTTLT KGYQLHVLSF TVHSILVATS QDFMVGDLDQ
DLPVLASIIM DDIFGTVGQE KDAEDYVSKM KEVKASKSFD SMELLAKNAS VRHVYNLVQP
IQRLLEERLT SSIVKKVDEL LRRIATGLLR NPGVESRDFL IFCYQVIKES YKTTDPSQPD
AAAQPKDRFI VKMIAFNKSG TGRSTSSYLY KLARFSLDAL RSVLNKYNSL LTAENLSGFL
PIIGDALVQG YEEVKIAAIR LLSTIIKLPL EEIDKSSDVY LVEAIKLIKE APSTNTEGAQ
AAIKLIASIL RERRSIKLKD SHLAYMLKRI SGDIEEPDRQ GITFNFIRAV MARKLIVPEM
YELVDNIAAM MVTNHTRNAR DLARGVYVHF LIEYPQTKNR WSKQLGYLTK NLDYRHKEGR
QSVLEAVHLL LTKTNGELAQ DIVGTFFVPI VMVMANDESP ECREMAGILL NGIYSCAEPE
QLKPILSSLR MWLERTENLS LITAGLQAAR IFFESNAGDK ENEAQFVTNL LPRLMDIPLE
NPSSEEWETL YYSLQLFIKL SKLFPAISLS PSCAPIWSKV RQSLFFPHGW IKSCAANLIG
TWLADEAKAN AANGYGAIPL VGSSGLKLDE NTMLDLTRGC IFCLKTPTVS EELATQTIRN
LVFLGRCFGQ NDLYLPVKHV NGCKDSDSES EVEEVTEPSK EPKKAIQYIF EQAAKILRRE
PLTTKAESLR GKTACMKLIA ALCSHLETGQ LLPSLQKILL PLLHLTDPSI PPPRSSDENF
RAAYKVLVES SQEILDLLQK KFGTTEFVTE LSRARDNIRT RRDERRVKRK IEAVADPEKF
GREKKRKNER KKEKRKEKGL GFRDRRRGW
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