ID J3KJ49_COCIM Unreviewed; 498 AA.
AC J3KJ49;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 2.
DT 03-MAY-2023, entry version 51.
DE SubName: Full=Transmembrane transporter {ECO:0000313|EMBL:EAS36050.3};
GN ORFNames=CIMG_01404 {ECO:0000313|EMBL:EAS36050.3};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS36050.3, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG704911; EAS36050.3; -; Genomic_DNA.
DR RefSeq; XP_001247633.1; XM_001247632.2.
DR AlphaFoldDB; J3KJ49; -.
DR GeneID; 4566467; -.
DR KEGG; cim:CIMG_01404; -.
DR VEuPathDB; FungiDB:CIMG_01404; -.
DR InParanoid; J3KJ49; -.
DR OMA; ILLCQGP; -.
DR OrthoDB; 1355077at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR43791; PERMEASE-RELATED; 1.
DR PANTHER; PTHR43791:SF52; TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11820)-RELATED; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:EAS36050.3};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 48..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..195
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..466
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 498 AA; 55161 MW; 0D0D12511AC9EB67 CRC64;
MASESSEDKI GPKLANREKS DVESGDGGSS SQLSVSPRKV LRKIDMHLMA PLWVVFVFGF
LDRINLGNVA VLGIMKELGQ VGNDFNIAVQ VFFVPYILLD IPSNIVLKKF TPSTWISLLT
FLWGVASMCQ GFVKNNGALI ACRFFIGVFE AGFVPGCAYL MAMYYKRHEF QKRFSLFWVA
GLVAGAFGGL LAYGLDHMRG LGGYSGWRWI FIMEGLMSIV LAVPAKFLIA DWPEQAKFLT
EEEKQYVLAR NSEDVGGGAR MDRLDAEAWK RIMSDWKIYV GSMIYIGITV SGYATALFIP
SIVNSLGYSG IDSQVHSIPI WVVAAVVTLI VSYLTDRLRH RFGFVVFGVI VASIGYIILL
CQGPPEGGLS PSVRYMAVFF VCTGTYIVQP VAIVWMANNL GGHYKRAIGL AIQVGFGNIG
GIIASNIFVM EDRPRYFVGY GVSLAMMIFC GVMSIVFAIG LVRENKLREQ GKRDDRLQLE
ERILGNMGDD DPRFRFTL
//
