ID J3KPQ8_HUMAN Unreviewed; 432 AA.
AC J3KPQ8;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Guanylate cyclase soluble subunit alpha-1 {ECO:0000256|ARBA:ARBA00040514};
DE AltName: Full=Soluble guanylate cyclase large subunit {ECO:0000256|ARBA:ARBA00042184};
GN Name=GUCY1A1 {ECO:0000313|Ensembl:ENSP00000377418.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000377418.3, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000377418.3, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000377418.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; AC104083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; J3KPQ8; -.
DR SMR; J3KPQ8; -.
DR MassIVE; J3KPQ8; -.
DR PeptideAtlas; J3KPQ8; -.
DR Antibodypedia; 4394; 341 antibodies from 35 providers.
DR Ensembl; ENST00000393832.7; ENSP00000377418.3; ENSG00000164116.17.
DR UCSC; uc063amp.1; human.
DR HGNC; HGNC:4685; GUCY1A1.
DR VEuPathDB; HostDB:ENSG00000164116; -.
DR GeneTree; ENSGT00940000158285; -.
DR HOGENOM; CLU_011614_1_1_1; -.
DR ChiTaRS; GUCY1A3; human.
DR Proteomes; UP000005640; Chromosome 4.
DR Bgee; ENSG00000164116; Expressed in urethra and 206 other cell types or tissues.
DR ExpressionAtlas; J3KPQ8; baseline and differential.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655:SF4; GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Proteomics identification {ECO:0007829|MaxQB:J3KPQ8,
KW ECO:0007829|PeptideAtlas:J3KPQ8};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 223..350
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 168..195
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 432 AA; 48463 MW; CC3939D0EADB1055 CRC64;
MKSTKPSLSP SKPQSSLVIP TSLFCKTFPF HFMFDKDMTI LQFGNGIRRL MNRRDFQGKP
NFEEYFEILT PKINQTFSGI MTMLNMQFVV RVRRWDNSVK KSSRVMDLKG QMIYIVESSA
ILFLGSPCVD RLEDFTGRGL YLSDIPIHNA LRDVVLIGEQ ARAQDGLKKR LGKLKATLEQ
AHQALEEEKK KTVDLLCSIF PCEVAQQLWQ GQVVQAKKFS NVTMLFSDIV GFTAICSQCS
PLQVITMLNA LYTRFDQQCG ELDVYKVETI GDAYCVAGGL HKESDTHAVQ IALMALKMME
LSDEVMSPHG EPIKMRIGLH SGSVFAGVVG VKMPRYCLFG NNVTLANKFE SCSVPRKINV
SPTTYRLLKD CPGFVFTPRS REELPPNFPS EIPGICHFLD AYQQGTNSKP CFQKKDVEDG
NANFLGKASG ID
//
