ID J3N953_ORYBR Unreviewed; 1121 AA.
AC J3N953;
DT 03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN Name=102702418 {ECO:0000313|EnsemblPlants:OB11G23390.1};
OS Oryza brachyantha (malo sina).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4533 {ECO:0000313|EnsemblPlants:OB11G23390.1};
RN [1] {ECO:0000313|EnsemblPlants:OB11G23390.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IRGC 101232 {ECO:0000313|EnsemblPlants:OB11G23390.1};
RX PubMed=23481403;
RA Chen J., Huang Q., Gao D., Wang J., Lang Y., Liu T., Li B., Bai Z.,
RA Luis Goicoechea J., Liang C., Chen C., Zhang W., Sun S., Liao Y., Zhang X.,
RA Yang L., Song C., Wang M., Shi J., Liu G., Liu J., Zhou H., Zhou W., Yu Q.,
RA An N., Chen Y., Cai Q., Wang B., Liu B., Min J., Huang Y., Wu H., Li Z.,
RA Zhang Y., Yin Y., Song W., Jiang J., Jackson S.A., Wing R.A., Wang J.,
RA Chen M.;
RT "Whole-genome sequencing of Oryza brachyantha reveals mechanisms underlying
RT Oryza genome evolution.";
RL Nat. Commun. 4:1595-1595(2013).
RN [2] {ECO:0000313|EnsemblPlants:OB11G23390.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (APR-2013) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|ARBA:ARBA00009085}.
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DR RefSeq; XP_015697994.1; XM_015842508.1.
DR AlphaFoldDB; J3N953; -.
DR STRING; 4533.J3N953; -.
DR EnsemblPlants; OB11G23390.1; OB11G23390.1; OB11G23390.
DR GeneID; 102702418; -.
DR Gramene; OB11G23390.1; OB11G23390.1; OB11G23390.
DR KEGG; obr:102702418; -.
DR eggNOG; KOG1863; Eukaryota.
DR HOGENOM; CLU_003532_0_1_1; -.
DR OMA; INAKKHY; -.
DR OrthoDB; 51419at2759; -.
DR Proteomes; UP000006038; Chromosome 11.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00121; MATH; 1.
DR CDD; cd02659; peptidase_C19C; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR024729; USP7_ICP0-binding_dom.
DR InterPro; IPR029346; USP_C.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR24006:SF941; UBIQUITINYL HYDROLASE 1; 1.
DR Pfam; PF00917; MATH; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF14533; USP7_C2; 1.
DR Pfam; PF12436; USP7_ICP0_bdg; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000006038};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 61..186
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT DOMAIN 206..530
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1121 AA; 131290 MW; 8956F03C0987E823 CRC64;
MTMMTPPPLE PEEDEMLVPH QELAAADADA DAAAAAQPME VVAQTEAAST AESQPAEDPQ
TSRFTWTIEN FTRINAKKHY SDVFVVGAYK WRVLIFPKGN NVDHFSMYLD VADSANLPYG
WSRYAQFSLA VVNQIQQKYT IRKDTQHQFN ARESDWGFTS FMPLSELYDP GRGYLVDDTI
VVEAEVAVRK MVDYWTYDSK KETGYVGLKN QGATCYMNSL LQTLYHIPYF RKAVYHMPTT
ENDMPSGSIP LALQSLFYKL QYSDNSVATK ELTKSFGWDT YDSFMQHDVQ ELNRVLCEKL
EDKMKGTVVE GTIEQLFEGH HINYIECINV DYKSNRKESF YDLQLDVKGC RDVYASFDKY
VEVERLEGDN KYQAENHGLQ DAKKGVLFLD FPPVLQLQLK RFEYDYMRDT MVKINDRYEF
PLQLDLDIED GKYLAPDADR SIRNLYALHS VLVHSGGVHG GHYYAFIRPT LSDQWYKFDD
ERVTKEDTKK ALEEQYGGEE ELPQINLGFN NAPFKFTKYS NAYMLVYIRE SDKDKIMCNV
DEKDIAEHLR IRLKKEQEEK EHKKKEKAEA HLYTIIKVAR DENLKEQIGK DIYFDLVDHE
KVRSFRIQKQ LPFSTFKEEV AKEYGIPVQF QRFWLWAKRQ NHTYRPNRPL SPHDETQSVG
QLREVSNKAH NAELKLFLEV ELGLDLRPLP PPEKSKEDIL LFFKLYNPEK EELCFVGRLF
VKALGKPSEI LTKLNEMAGF TPNEEIELYE EIKFEPNVMC EHIDKKITFR ASQLEDGDII
CFQKSHRDTQ VRYPDVPSYL EYVHNRQVVH FRLLEKPKDD DFCLELSKLH TYDDVVERVA
GQLGVDDPAK IRLTSHNCYS QQPKPQPIRY RGVEHLLDML IHYNQTSDIL YYEVLDIPLP
ELQGLKTLKV AFHHATKDEV VIHSIRLPKN STIEDVINDL KTKVELSSPS AELRLLEVFY
HKIYKIFPLH EKIENINDQY WTLRAEEIPE EEKNLGPQDR LIHVYHFMKD PLQNQQIQNF
GDPFYLAIRE GETLAEVKER IQKKLQVPNE EFCKWKFAFI SMNRPDYLQD SDIVSARFQR
RDVYGAWEQY LGLEHTDTAP KRAYTANQNR HTYEKPVRIY N
//
