ID J3SCF6_CROAD Unreviewed; 686 AA.
AC J3SCF6;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Guanylate cyclase soluble subunit alpha-1 {ECO:0000256|ARBA:ARBA00040514};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
DE AltName: Full=Soluble guanylate cyclase large subunit {ECO:0000256|ARBA:ARBA00042184};
OS Crotalus adamanteus (Eastern diamondback rattlesnake).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX NCBI_TaxID=8729 {ECO:0000313|EMBL:AFJ50270.1};
RN [1] {ECO:0000313|EMBL:AFJ50270.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Venom gland {ECO:0000313|EMBL:AFJ50270.1};
RX PubMed=23025625; DOI=10.1186/1471-2164-13-312;
RA Rokyta D.R., Lemmon A.R., Margres M.J., Aronow K.;
RT "The venom-gland transcriptome of the eastern diamondback rattlesnake
RT (Crotalus adamanteus).";
RL BMC Genomics 13:312-312(2012).
RN [2] {ECO:0000313|EMBL:JAI13214.1}
RP NUCLEOTIDE SEQUENCE.
RA Margres M.J., Wray K.P., McGivern J.J., Seavy M., Sanader D., Facente J.,
RA Rokyta D.R.;
RT "The extremes of toxin expression variation revealed in two sympatric snake
RT species.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; JU174744; AFJ50270.1; -; mRNA.
DR EMBL; GBEX01001346; JAI13214.1; -; mRNA.
DR AlphaFoldDB; J3SCF6; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655:SF4; GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134}.
FT DOMAIN 477..604
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 422..449
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 686 AA; 77433 MW; 98B8FDD6F741E23D CRC64;
MFCTKLKELK ITGECPFSLL NQSCIPDENE EECAEVPNSS KTPLPICREK VPHGNLPQRK
ISKNRVFLHT LAETIYKLIS PEYEKLCLAF QRSLANNNIK EIRQCGEKDF EKLLTDHANL
AGIPVTVIRE SLGEELFKIC YEEDEHILGV VGGSLKDFLN SFSTLLKQSS HCHEAGKMGR
VEEVSILCLE KDPNFLNVYY FSPQKPTTLI LSGIIKAAAL ILYDMEVEVM VMPPSFCKDS
SEFIDQPYLL YSVHVKSTKP SLSPCKPQSS LVIPTSMFYK TFPFHCMFDK GMVILQFGNG
IRRLLNKREF QAKPQFHEWF EILAPKINCT FSGIMTMLNM QFNIRVRQGD KVLKKSTGVM
DLKGQMIYII ESNAILFLGS PCVDRLEDFT GRGLYLSDIP IHNALRDVVL IGEQARAQDG
LKKRLGKLKV TLEQAHQALE EEKKKTVDLL CSIFPEEVAQ QLWQGQVVQA KKFNNVTMLF
SDIVGFTAIC SQCSPMQVIT MLNELYTRFD YQCGELDIYK VETIGDAYCV AGGLHKENET
HAIQIALMAL KMMVLSNEVM SPHGESIKMR IGLHSGSVFA GVVGVKMPRY CLFGNNVTLA
NKFESCSIPR KINVSPTTYR LIKDHPGFVF TPRSRQELPP NFPSDIPGIC YFLDAYLQGK
STKAWFQKKD AEEDKTNFLG ISTGVD
//
