ID J3T3G7_ABRGR Unreviewed; 202 AA.
AC J3T3G7;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE Flags: Fragment;
GN Name=NT3 {ECO:0000313|EMBL:AFP73685.1};
OS Abronia graminea (Terrestrial arboreal alligator lizard) (Gerrhonotus
OS gramineus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Anguimorpha; Neoanguimorpha; Anguioidea; Anguidae; Abronia.
OX NCBI_TaxID=278977 {ECO:0000313|EMBL:AFP73685.1};
RN [1] {ECO:0000313|EMBL:AFP73685.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22809723; DOI=10.1098/rsbl.2012.0460;
RA Vidal N., Marin J., Sassi J., Battistuzzi F.U., Donnellan S., Fitch A.J.,
RA Fry B.G., Vonk F.J., Rodriguez de la Vega R.C., Couloux A., Hedges S.B.;
RT "Molecular evidence for an Asian origin of monitor lizards followed by
RT Tertiary dispersals to Africa and Australasia.";
RL Biol. Lett. 0:853-855(2012).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JQ844947; AFP73685.1; -; Genomic_DNA.
DR AlphaFoldDB; J3T3G7; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW Growth factor {ECO:0000256|RuleBase:RU365037};
KW Secreted {ECO:0000256|RuleBase:RU365037};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 120..202
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFP73685.1"
FT NON_TER 202
FT /evidence="ECO:0000313|EMBL:AFP73685.1"
SQ SEQUENCE 202 AA; 22995 MW; 62E7B1B06A4483CE CRC64;
LPEGSINSLI IKLIQADILK NKDSRQVIDI KESVQDPLKK TDSVEPSIDD HENVKLGFPP
VISMDTELLR QQRRYSSPRV LFSDNTPLEP PPLYLMEDYI GSSVVVNRTS RRKRFAENKS
HRGEYSVCDS ESRWVTDKSS AIDIRGHQVT VLGEIKMGPS PVKQYFYETR CKQAKPAKSG
CRGIDDKHWN SQCKTSQTFV RA
//
