ID J3TEY3_9ENTR Unreviewed; 238 AA.
AC J3TEY3;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 28-FEB-2018, entry version 34.
DE RecName: Full=DnaA regulatory inactivator Hda {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00634471};
GN Name=hda {ECO:0000256|HAMAP-Rule:MF_01158};
GN ORFNames=A359_00980 {ECO:0000313|EMBL:AFP84502.1};
OS secondary endosymbiont of Ctenarytaina eucalypti.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; aphid secondary symbionts.
OX NCBI_TaxID=1199245 {ECO:0000313|EMBL:AFP84502.1, ECO:0000313|Proteomes:UP000003936};
RN [1] {ECO:0000313|EMBL:AFP84502.1, ECO:0000313|Proteomes:UP000003936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22821013; DOI=10.1093/molbev/mss180;
RA Sloan D.B., Moran N.A.;
RT "Genome reduction and co-evolution between the primary and secondary
RT bacterial symbionts of psyllids.";
RL Mol. Biol. Evol. 29:3781-3792(2012).
CC -!- FUNCTION: Mediates the interaction of DNA replication inititator
CC protein DnaA with DNA polymerase subunit beta sliding clamp
CC (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering
CC DnaA inactive for reinititation, a process called regulatory
CC inhibition of DnaA or RIDA. {ECO:0000256|HAMAP-Rule:MF_01158}.
CC -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms
CC the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA,
CC ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
CC {ECO:0000256|HAMAP-Rule:MF_01158}.
CC -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01158, ECO:0000256|SAAS:SAAS00548763}.
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DR EMBL; CP003546; AFP84502.1; -; Genomic_DNA.
DR RefSeq; WP_014887800.1; NC_018419.1.
DR EnsemblBacteria; AFP84502; AFP84502; A359_00980.
DR KEGG; sect:A359_00980; -.
DR PATRIC; fig|1199245.3.peg.116; -.
DR KO; K10763; -.
DR OrthoDB; POG091H0GIW; -.
DR BioCyc; SEND1199245:G1H9E-81-MONOMER; -.
DR Proteomes; UP000003936; Chromosome.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0032297; P:negative regulation of DNA-dependent DNA replication initiation; IEA:InterPro.
DR HAMAP; MF_01158; Hda; 1.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR017788; Hda.
DR InterPro; IPR022864; Hda_Enterobact.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00308; Bac_DnaA; 1.
DR PRINTS; PR00051; DNAA.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR03420; DnaA_homol_Hda; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Complete proteome {ECO:0000313|Proteomes:UP000003936};
KW DNA replication {ECO:0000256|HAMAP-Rule:MF_01158,
KW ECO:0000256|SAAS:SAAS00634466};
KW DNA replication inhibitor {ECO:0000256|HAMAP-Rule:MF_01158,
KW ECO:0000256|SAAS:SAAS00634468};
KW Reference proteome {ECO:0000313|Proteomes:UP000003936}.
FT DOMAIN 21 218 Bac_DnaA. {ECO:0000259|Pfam:PF00308}.
FT COILED 199 219 {ECO:0000256|SAM:Coils}.
SQ SEQUENCE 238 AA; 27148 MW; 99A4FC60082DD6BC CRC64;
MREVPLNTSS QLSLPLYLPD DETFASFYPG QNGALLAALQ DMLSRERVSY LYFWSRKGGG
RSHLLHAACA KLSAHAQAVG YVPLDKRTWF VPEVLDGMEQ LALVTIDNIQ CIVGDPPWEM
AIFNLYNRIQ ETRRTRLIIS GNCPPRQLKL SLPDLASRLD WGQIYRLQPL SDEEKSAALQ
LRAKLRGFEL PEDVRRFLLK RIERDMRTLS ATLNQLDNAS IQAQRKLTIP FVKVILNL
//
