ID J3TKK7_VARSC Unreviewed; 223 AA.
AC J3TKK7;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:AFP73763.1};
OS Varanus scalaris (Banded tree monitor) (Varanus timorensis scalaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus.
OX NCBI_TaxID=169852 {ECO:0000313|EMBL:AFP73763.1};
RN [1] {ECO:0000313|EMBL:AFP73763.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22809723; DOI=10.1098/rsbl.2012.0460;
RA Vidal N., Marin J., Sassi J., Battistuzzi F.U., Donnellan S., Fitch A.J.,
RA Fry B.G., Vonk F.J., Rodriguez de la Vega R.C., Couloux A., Hedges S.B.;
RT "Molecular evidence for an Asian origin of monitor lizards followed by
RT Tertiary dispersals to Africa and Australasia.";
RL Biol. Lett. 0:853-855(2012).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|ARBA:ARBA00002323, ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; JQ845025; AFP73763.1; -; Genomic_DNA.
DR AlphaFoldDB; J3TKK7; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 119..223
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFP73763.1"
FT NON_TER 223
FT /evidence="ECO:0000313|EMBL:AFP73763.1"
SQ SEQUENCE 223 AA; 25106 MW; 6A3E9CBAF7ACAE93 CRC64;
SCMKAAPMKE VSLRGQGSLA YPGLRTQGNL ESMGGPNDAT RGLTSLADTF EHVIEELLDE
QEVIQPSKEN KDADLYSSRV MLSSQVPLEP PLLFLLEEYK NYLDAANMSM RVRRHSDPAR
RGELSVCDSI SEWVTAADKK TAVDMSGATV TVLEKVPVPK GQLKQYFYET KCNSKGYTKE
GCRGIDKRYW NSQCRTTQSY VRALTMDNKK RVGWRFIRID TSC
//
