ID J3YI49_ANGFR Unreviewed; 196 AA.
AC J3YI49;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Bone morphogenetic protein 2 {ECO:0000313|EMBL:AFP73732.1};
DE Flags: Fragment;
GN Name=BMP2 {ECO:0000313|EMBL:AFP73732.1};
OS Anguis fragilis (Slow worm).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Anguimorpha; Neoanguimorpha; Anguioidea; Anguidae; Anguis.
OX NCBI_TaxID=102178 {ECO:0000313|EMBL:AFP73732.1};
RN [1] {ECO:0000313|EMBL:AFP73732.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22809723; DOI=10.1098/rsbl.2012.0460;
RA Vidal N., Marin J., Sassi J., Battistuzzi F.U., Donnellan S., Fitch A.J.,
RA Fry B.G., Vonk F.J., Rodriguez de la Vega R.C., Couloux A., Hedges S.B.;
RT "Molecular evidence for an Asian origin of monitor lizards followed by
RT Tertiary dispersals to Africa and Australasia.";
RL Biol. Lett. 0:853-855(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; JQ844994; AFP73732.1; -; Genomic_DNA.
DR AlphaFoldDB; J3YI49; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF143; BONE MORPHOGENETIC PROTEIN 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 103..196
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 95..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..115
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFP73732.1"
FT NON_TER 196
FT /evidence="ECO:0000313|EMBL:AFP73732.1"
SQ SEQUENCE 196 AA; 22419 MW; 5E821D11553BEF9F CRC64;
LHPEREASKD PVTRLLDTRL VHHNASKWET FDVTPAIMRW IAHGQPNHGF VVEVVHLDKE
SSVSKRHVRI SRSLHQDDAS WSQIRPLLVT FGHDGKGHPL HKREKRQTKQ KPRKRHKFNC
KRHPLYVDFN DVGWNDWIVA PPGYGAFYCH GDCPFPLADH LNSTNHAIVQ TLVNSVNSKI
PKACCVPTEL SAISML
//
