ID J4DNF5_THEOR Unreviewed; 499 AA.
AC J4DNF5;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=ATP-dependent RNA helicase {ECO:0000256|RuleBase:RU365068};
DE EC=3.6.4.13 {ECO:0000256|RuleBase:RU365068};
GN ORFNames=TOT_010000336 {ECO:0000313|EMBL:BAM38869.1};
OS Theileria orientalis strain Shintoku.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Theileriidae; Theileria.
OX NCBI_TaxID=869250 {ECO:0000313|EMBL:BAM38869.1, ECO:0000313|Proteomes:UP000003786};
RN [1] {ECO:0000313|EMBL:BAM38869.1, ECO:0000313|Proteomes:UP000003786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shintoku {ECO:0000313|EMBL:BAM38869.1,
RC ECO:0000313|Proteomes:UP000003786};
RX PubMed=22951932;
RA Hayashida K., Hara Y., Abe T., Yamasaki C., Toyoda A., Kosuge T.,
RA Suzuki Y., Sato Y., Kawashima S., Katayama T., Wakaguri H., Inoue N.,
RA Homma K., Tada-Umezaki M., Yagi Y., Fujii Y., Habara T., Kanehisa M.,
RA Watanabe H., Ito K., Gojobori T., Sugawara H., Imanishi T., Weir W.,
RA Gardner M., Pain A., Shiels B., Hattori M., Nene V., Sugimoto C.;
RT "Comparative genome analysis of three eukaryotic parasites with differing
RT abilities to transform leukocytes reveals key mediators of Theileria-
RT induced leukocyte transformation.";
RL MBio 3:e00204-e00212(2012).
CC -!- FUNCTION: RNA helicase. {ECO:0000256|RuleBase:RU365068}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|RuleBase:RU365068};
CC -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD box
CC family of RNA helicases and controls ATP binding and hydrolysis.
CC {ECO:0000256|RuleBase:RU365068}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX51/DBP6
CC subfamily. {ECO:0000256|ARBA:ARBA00038200}.
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DR EMBL; AP011946; BAM38869.1; -; Genomic_DNA.
DR RefSeq; XP_009689170.1; XM_009690875.1.
DR AlphaFoldDB; J4DNF5; -.
DR STRING; 869250.J4DNF5; -.
DR EnsemblProtists; BAM38869; BAM38869; TOT_010000336.
DR GeneID; 20713262; -.
DR KEGG; tot:TOT_010000336; -.
DR VEuPathDB; PiroplasmaDB:TOT_010000336; -.
DR eggNOG; KOG0350; Eukaryota.
DR OrthoDB; 228169at2759; -.
DR Proteomes; UP000003786; Chromosome 1.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24031:SF68; ATP-DEPENDENT RNA HELICASE DDX51; 1.
DR PANTHER; PTHR24031; RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU365068};
KW Helicase {ECO:0000256|RuleBase:RU365068, ECO:0000313|EMBL:BAM38869.1};
KW Hydrolase {ECO:0000256|RuleBase:RU365068};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365068};
KW Reference proteome {ECO:0000313|Proteomes:UP000003786};
KW RNA-binding {ECO:0000256|RuleBase:RU365068}.
FT DOMAIN 73..270
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 301..455
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 499 AA; 57878 MW; FBCB861BDC17499E CRC64;
MNTVLSDLKE NPLWAYRVSS YSNESSGLSC DKLLKKWNFH RYVRKVIKDK HITEFFPIQE
KIIPLLLNNT YKDRLSVFSC DFIITAPTGQ GKTLCYVLPL INNILNLKEN RLSALIIAPS
RELVKQIYEV FSWFIDSDPL TYDLKGNGLK VRLFYGDKSF IKYHRTILND PPHIAITTPG
ILVEYFIDFD KNHFYNTFSH LKWIVIEEVD LMLNQPLFEW VNVVVDLVNT LKRSESNQCS
GLPQKILVSA TVPLKSHEID TLDLNRPILF RLDEIIFKLP KNLTQNCIST SKRSRPLVLI
KLLNFLFFEK ESGNVLVFFS KVDTCHTIAR LLQIYVHQTK SNFKAMEFNS KLSQKDRNRV
MNTYKKEGKI CLLCSDVASR GIDLPNTTVV VSYDVPIRLS TYIHRAGRTA RANNEGNLYV
FVSKKDQTNY NRFMNKLKVE RSEINNIDPN GLMSEQKSNK LKEIYPKLVE NGEKCLDLES
SGKIKYHSEL KESWYLIDS
//
