ID J4GPC2_9APHY Unreviewed; 305 AA.
AC J4GPC2;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN ORFNames=FIBRA_04481 {ECO:0000313|EMBL:CCM02385.1};
OS Fibroporia radiculosa.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Fibroporiaceae; Fibroporia.
OX NCBI_TaxID=599839 {ECO:0000313|EMBL:CCM02385.1, ECO:0000313|Proteomes:UP000006352};
RN [1] {ECO:0000313|EMBL:CCM02385.1, ECO:0000313|Proteomes:UP000006352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TFFH 294 {ECO:0000313|EMBL:CCM02385.1,
RC ECO:0000313|Proteomes:UP000006352};
RX PubMed=22247176; DOI=10.1128/AEM.06745-11;
RA Tang J.D., Perkins A.D., Sonstegard T.S., Schroeder S.G., Burgess S.C.,
RA Diehl S.V.;
RT "Short-read sequencing for genomic analysis of the brown rot fungus
RT Fibroporia radiculosa.";
RL Appl. Environ. Microbiol. 78:2272-2281(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR EMBL; HE797078; CCM02385.1; -; Genomic_DNA.
DR RefSeq; XP_012181668.1; XM_012326278.1.
DR AlphaFoldDB; J4GPC2; -.
DR STRING; 599839.J4GPC2; -.
DR GeneID; 24097296; -.
DR HOGENOM; CLU_912256_0_0_1; -.
DR InParanoid; J4GPC2; -.
DR OrthoDB; 374620at2759; -.
DR Proteomes; UP000006352; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006352}.
FT DOMAIN 120..261
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
SQ SEQUENCE 305 AA; 33143 MW; 53567D96221761D5 CRC64;
MADHTDSLTV HGEHGTTIFT LSGPTLVVHR ASDSEFHSPP VRVSPHGGPT EKWPRIETTV
RHVLWAEVKE NLFEIALVAR RKNSHPLSLV LVAGTVKSDQ LEIATAFTTS LMDVAYAGIR
RQRRLRVLVN PKSGPGNGIG LYHRKVEPIF RAAHCHVELT LTTHHGHAYE LMKTLDLGQY
DAIVVVSGDG LVHEIINGFA EHARPEEAFR LPITPVAGGS GNALALNILG PKEGCDICAA
ALNAVKGRPM RIDLCSVTQG EKKTLSFISQ CVGMLADVDL GTEHLRFLGS NRFVLGYVYG
GDIFS
//
