ID J4H234_9APHY Unreviewed; 1116 AA.
AC J4H234;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181, ECO:0000256|PIRNR:PIRNR036945};
GN ORFNames=FIBRA_02871 {ECO:0000313|EMBL:CCM00829.1};
OS Fibroporia radiculosa.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Fibroporiaceae; Fibroporia.
OX NCBI_TaxID=599839 {ECO:0000313|EMBL:CCM00829.1, ECO:0000313|Proteomes:UP000006352};
RN [1] {ECO:0000313|EMBL:CCM00829.1, ECO:0000313|Proteomes:UP000006352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TFFH 294 {ECO:0000313|EMBL:CCM00829.1,
RC ECO:0000313|Proteomes:UP000006352};
RX PubMed=22247176; DOI=10.1128/AEM.06745-11;
RA Tang J.D., Perkins A.D., Sonstegard T.S., Schroeder S.G., Burgess S.C.,
RA Diehl S.V.;
RT "Short-read sequencing for genomic analysis of the brown rot fungus
RT Fibroporia radiculosa.";
RL Appl. Environ. Microbiol. 78:2272-2281(2012).
CC -!- FUNCTION: The SPT4-SPT5 complex mediates both activation and inhibition
CC of transcription elongation, and plays a role in pre-mRNA processing.
CC This complex seems to be important for the stability of the RNA
CC polymerase II elongation machinery on the chromatin template but not
CC for the inherent ability of this machinery to translocate down the
CC gene. {ECO:0000256|ARBA:ARBA00024691, ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
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DR EMBL; HE797006; CCM00829.1; -; Genomic_DNA.
DR RefSeq; XP_012180112.1; XM_012324722.1.
DR AlphaFoldDB; J4H234; -.
DR STRING; 599839.J4H234; -.
DR GeneID; 24095740; -.
DR HOGENOM; CLU_003537_1_0_1; -.
DR InParanoid; J4H234; -.
DR OrthoDB; 24955at2759; -.
DR Proteomes; UP000006352; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF12815; CTD; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM00739; KOW; 6.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Reference proteome {ECO:0000313|Proteomes:UP000006352};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945}.
FT DOMAIN 171..261
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 266..293
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 427..454
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 480..507
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 602..627
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 695..722
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 1062..1089
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 1..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..56
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..100
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..803
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1116 AA; 122679 MW; 7B52E5785C8D072C CRC64;
MSDAEEDAPF NNEGFEENEE VEEEEDEEEE ENPPKPSRRD YDDDEEDEED EEDEEDMGAE
RGKKRPKRTK RSAVGRFLDV EAEVDEDEED EDEEDEYARD EFVVGGEADE DDLARRAADH
ARFDRREREL DDQDLAKIAE DVSQRYRRTA VRYSGDMSDI PQRLLMPSVH DANLWQVRVR
PGKERDLVFS LMRKAIDLEY SNRPLQIVSA FQRDSLPGMI YVEARSAKQV SDACNGLVGI
YPSRGIILVP IEEMASLLQI KKQDLTVTPG SWVRIRRGKY QGDIAQVMDI TENGEEVGLK
FIPRIDLNPK DDGSVEIMGK KRKKGPTGIS SSSMRPPQRF FNYEEVVKVY GRKAVSKRNQ
VYVFQNETYK DGFIEKDFKL AGLQLDNVNP TLDEITRFTH GQDGAENDAN VDLSIIAEAS
RKAAISVLQP GDHVEVFEGE QSGVHGTVHS IEQDIVSIQP VGVDFDGQRI QLPARSVRKR
FKPGDHVKVM TGQNADETGL VVSVSANVVT FLSDMSMQEV SVFSKDLREA AEVGTGTNVV
GNYELHDLVQ LDMQTVGVIF KTERDSFRVL DQNGQVRLVQ PHQISMRRDS NRAIATDAEG
HELRVNDNVK EVDGEGRKGR VLHTHQSFFA FLHNRDYNEH GGVFVTRARS LVSVAPKGNI
MKLGAADLSK MNPALSGGAM GGMVGSGNIG RGPRDRLIGV PVTVVKGPSK GYIGTIKDTN
GAIARVELNT GNKVISIDKM KLMWRKPPTG VLEPLENAIA GRPSQGGGST RTPNPYNNRS
SFGQRTGAQT PWDNRTPAWE TNRTPNPYAA AGKTPAWNAA SRTPNPYADG GRTPAWNSAS
RTPNPYTNGN ASPARPAGGA WGGATPGRSG WGGAASPRQT GWASPARPSG AWAEAPSGPW
LLKTVQGEPP LSAPTPGFAP YTPGADLGVT PAAAATPGVF DAYADLRTPL AVFSDHRNAV
STPGVSVGMF ANQEGEFELP LRWLLETDIS NKRGMMVEVR SSHGANGWYN GEYEGKQGVV
LSIFDTHSEQ FPSTARVQFP EPLDPSQPII QVPVEVLAPI HPEKPNEEVL ILHGPQKGQM
AKVNMVEPGG TMVVTTRMFV VEEITSDKLV RIQADV
//
