ID   J4I8Z1_9APHY            Unreviewed;      1007 AA.
AC   J4I8Z1;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 34.
DE   RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN   ORFNames=FIBRA_02280 {ECO:0000313|EMBL:CCM00251.1};
OS   Fibroporia radiculosa.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Fibroporiaceae; Fibroporia.
OX   NCBI_TaxID=599839 {ECO:0000313|EMBL:CCM00251.1, ECO:0000313|Proteomes:UP000006352};
RN   [1] {ECO:0000313|EMBL:CCM00251.1, ECO:0000313|Proteomes:UP000006352}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TFFH 294 {ECO:0000313|EMBL:CCM00251.1,
RC   ECO:0000313|Proteomes:UP000006352};
RX   PubMed=22247176; DOI=10.1128/AEM.06745-11;
RA   Tang J.D., Perkins A.D., Sonstegard T.S., Schroeder S.G., Burgess S.C.,
RA   Diehl S.V.;
RT   "Short-read sequencing for genomic analysis of the brown rot fungus
RT   Fibroporia radiculosa.";
RL   Appl. Environ. Microbiol. 78:2272-2281(2012).
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU367072}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC       {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR   EMBL; HE796973; CCM00251.1; -; Genomic_DNA.
DR   RefSeq; XP_012179534.1; XM_012324144.1.
DR   AlphaFoldDB; J4I8Z1; -.
DR   STRING; 599839.J4I8Z1; -.
DR   GeneID; 24095162; -.
DR   HOGENOM; CLU_005943_1_0_1; -.
DR   InParanoid; J4I8Z1; -.
DR   OrthoDB; 38995at2759; -.
DR   Proteomes; UP000006352; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR   PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR   Pfam; PF12460; MMS19_C; 2.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU367072};
KW   DNA repair {ECO:0000256|RuleBase:RU367072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006352};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          38..298
FT                   /note="MMS19 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14500"
FT   DOMAIN          546..871
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
FT   DOMAIN          891..966
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
SQ   SEQUENCE   1007 AA;  111452 MW;  4D7AF1932AB8870D CRC64;
     MESLDRPIRT WIASEREEEV IAVVSEISSG NATLLDVVKS LGKYLTAEED ELRTKGVDFL
     SLVLSKCPAE KMNRQSVRVL VAFYCGKLED TETIVPALKG LVSLTAMPDL TSIDAVEVMK
     ALINHVRMKV LIQSQRFTVY KIVDTLIANQ RDALKGMGKE FLSGYISLAE GEKDPRNLLI
     SFAIDRVLLL EFDVAAHVED LFNITFCYFP ITFRPPPDDP YGITTDDLKN ALSACLHATP
     LFGPLAIPLF LEKLTAGTPI TKRDTLKALD VSLPVYGASV ARNHARKLWN SLKLEIFQPT
     DIITEEAALH TTQVLIRTIY SADDSESPSD KEEVHGLAKE ACDECIEVLR EPEKSQAKPA
     IKVLCAFMST TPSVAKHTLS RTTPHLVKLF LDPDEMTNRG PILRLLADFI VASRDSMSKD
     SEVLPAEDDV PLLSYKDEVL GILTVGLKTP SSAQPALDGL KGMVTTRGLL TDEEIGFVVH
     NVNELLQKEG EESDEVSDYA LNLLTVISDF ASNHVSQTTL PLLFSSLPDR APPRDAQPER
     LKYWRTLASL TRLCKQPDLF ETLVVRLLTK LDLVCVPPTT AVNELESDTE PSAAYAHSLL
     RTISDVLAAK VDAGHSDVMK FIDRLVPRLY NLFIYSALMS DSTCMVATDP RLISVTAHII
     TLVVQTLTAQ RQEAFVAVLF SGYLQGDVHQ LADGYQKIPT DKKFEPLAPD APGLHKNLLA
     LLSAAVVALY KEVPLPCPDE TTFLDTLLQW SCLCTDNVLQ RDAIAHTISS VVNKRAGGLS
     SLLSEKADRF WTTQVADPSV PSEKRRHALC IWIWMTKALL VRGDAAATNY VNRLFELFDD
     AEISWDAARG VGSAIGTDKV LTKRNHAVIK VTSVLIMPYH IRADTDMFID FLLPLLLRGL
     DLPDTEIRAA IMDTLFTAAQ SGSKENNVVS EHASTLVSTM LKNCMVQETP SMRVRTAALR
     FLAILPNTVR YDVLHPYKAT VIRELVKVLD DPKRAVRQEA VEARTNW
//