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Database: UniProt
Entry: J4JUK9_9MYCO
LinkDB: J4JUK9_9MYCO
Original site: J4JUK9_9MYCO 
ID   J4JUK9_9MYCO            Unreviewed;       501 AA.
AC   J4JUK9;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 60.
DE   RecName: Full=Cobyric acid synthase {ECO:0000256|HAMAP-Rule:MF_00028};
GN   Name=cobQ {ECO:0000256|HAMAP-Rule:MF_00028};
GN   ORFNames=MCOL_V221266 {ECO:0000313|EMBL:EJO87467.1};
OS   Mycobacterium colombiense CECT 3035.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=1041522 {ECO:0000313|EMBL:EJO87467.1, ECO:0000313|Proteomes:UP000006455};
RN   [1] {ECO:0000313|EMBL:EJO87467.1, ECO:0000313|Proteomes:UP000006455}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 3035 {ECO:0000313|EMBL:EJO87467.1,
RC   ECO:0000313|Proteomes:UP000006455};
RX   PubMed=21952541; DOI=10.1128/JB.05928-11;
RA   Gonzalez-Perez M., Murcia M.I., Landsman D., Jordan I.K.,
RA   Marino-Ramirez L.;
RT   "Genome sequence of the Mycobacterium colombiense type strain, CECT 3035.";
RL   J. Bacteriol. 193:5866-5867(2011).
CC   -!- FUNCTION: Catalyzes amidations at positions B, D, E, and G on
CC       adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine,
CC       and one molecule of ATP is hydrogenolyzed for each amidation.
CC       {ECO:0000256|HAMAP-Rule:MF_00028}.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004953, ECO:0000256|HAMAP-Rule:MF_00028}.
CC   -!- SIMILARITY: Belongs to the CobB/CobQ family. CobQ subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00028}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJO87467.1}.
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DR   EMBL; AFVW02000006; EJO87467.1; -; Genomic_DNA.
DR   RefSeq; WP_007775239.1; NZ_CP020821.1.
DR   AlphaFoldDB; J4JUK9; -.
DR   STRING; 1041522.GCA_002105755_00190; -.
DR   GeneID; 31529614; -.
DR   eggNOG; COG1492; Bacteria.
DR   OrthoDB; 9808302at2; -.
DR   UniPathway; UPA00148; -.
DR   Proteomes; UP000006455; Unassembled WGS sequence.
DR   GO; GO:0015420; F:ABC-type vitamin B12 transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd05389; CobQ_N; 1.
DR   CDD; cd01750; GATase1_CobQ; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00028; CobQ; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   InterPro; IPR002586; CobQ/CobB/MinD/ParA_Nub-bd_dom.
DR   InterPro; IPR033949; CobQ_GATase1.
DR   InterPro; IPR047045; CobQ_N.
DR   InterPro; IPR004459; CobQ_synth.
DR   InterPro; IPR011698; GATase_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00313; cobQ; 1.
DR   PANTHER; PTHR21343:SF1; COBYRIC ACID SYNTHASE; 1.
DR   PANTHER; PTHR21343; DETHIOBIOTIN SYNTHETASE; 1.
DR   Pfam; PF01656; CbiA; 1.
DR   Pfam; PF07685; GATase_3; 1.
DR   SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51274; GATASE_COBBQ; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573, ECO:0000256|HAMAP-
KW   Rule:MF_00028};
KW   Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962,
KW   ECO:0000256|HAMAP-Rule:MF_00028}.
FT   DOMAIN          6..232
FT                   /note="CobQ/CobB/MinD/ParA nucleotide binding"
FT                   /evidence="ECO:0000259|Pfam:PF01656"
FT   DOMAIN          259..433
FT                   /note="CobB/CobQ-like glutamine amidotransferase"
FT                   /evidence="ECO:0000259|Pfam:PF07685"
FT   ACT_SITE        338
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00028"
FT   ACT_SITE        425
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00028"
SQ   SEQUENCE   501 AA;  53338 MW;  A6324184DC13ACE5 CRC64;
     MTGALLVAGT SSDAGKSVVV AGLCRLLARR GVRVAPFKAQ NMSNNSAVTV EGGEIGRAQA
     IQARAAGLEP SVRFNPILLK PGSDRTSQLV IKGRVADSVS AKSYVRHRDQ LASVVLDELT
     CLRAEFDAVI CEGAGSPAEI NLRATDLANM GLARAARLPV LLVGDIDRGG LLAHLFGTVA
     VLEPDDQALI AGFIVNKFRG DRALLEPGLR RLHDLTGRPT YGVLPYADEL WLDAEDSLSV
     VAHRVIGTPA PPCGDQWLRV AAIRLPRISN STDVEALACE PGVLVRWVTD PADIADTDLI
     VIPGSKATVA DLGWLREHGL DDAITAHAGA GKPVLGICGG FQMLCSRLDD PVESGTAGVS
     GLGLLDADIA FDSEKTLRRW QRPLAGYEIH HGRVTRCDEE SWFAPDADRR PQGVVRGAVF
     GTHWHGLLDN DDFRRGWLRR VADAAGRGGF VVGDVNVAAH RDAQLDLAAD LLASHLDIEG
     VLSLLDGPPP RRPVLASRLS Q
//
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