ID J4KNP2_BEAB2 Unreviewed; 4814 AA.
AC J4KNP2;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:EJP66049.1};
GN ORFNames=BBA_05020 {ECO:0000313|EMBL:EJP66049.1};
OS Beauveria bassiana (strain ARSEF 2860) (White muscardine disease fungus)
OS (Tritirachium shiotae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=655819 {ECO:0000313|EMBL:EJP66049.1, ECO:0000313|Proteomes:UP000002762};
RN [1] {ECO:0000313|EMBL:EJP66049.1, ECO:0000313|Proteomes:UP000002762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARSEF 2860 {ECO:0000313|EMBL:EJP66049.1,
RC ECO:0000313|Proteomes:UP000002762};
RX PubMed=22761991; DOI=10.1038/srep00483;
RA Xiao G., Ying S.H., Zheng P., Wang Z.L., Zhang S., Xie X.Q., Shang Y.,
RA St Leger R.J., Zhao G.P., Wang C., Feng M.G.;
RT "Genomic perspectives on the evolution of fungal entomopathogenicity in
RT Beauveria bassiana.";
RL Sci. Rep. 2:483-483(2012).
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DR EMBL; JH725161; EJP66049.1; -; Genomic_DNA.
DR RefSeq; XP_008598339.1; XM_008600117.1.
DR STRING; 655819.J4KNP2; -.
DR GeneID; 19888032; -.
DR HOGENOM; CLU_000092_2_0_1; -.
DR InParanoid; J4KNP2; -.
DR OrthoDB; 1778695at2759; -.
DR Proteomes; UP000002762; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 7.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002762}.
FT DOMAIN 1589..1666
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2134..2210
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3203..3280
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4295..4368
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4814 AA; 531796 MW; 0686E63F1FA211F3 CRC64;
MHSAAAGLGL SVLNPSPTIL PGPTLLHQLV RPACDHIALE HLCKGEITKF SYKSLHDASD
ALASQIAQSC VSVHGQLIVP VLLQQCPDLY ITLLAILKAG GAFCPLNLDA PAERVQFILK
DVGAKVVITS PELSARIPRD AGVELLYASD SYEAIVQHHQ AVTRQITPHN YAYVMYTSGS
TGTPKGVSIS HSAATQALLA HDAHIPRFSR FFQFAAPTFD VSVFEIFFPL FRGETLISAS
RQETLDDLPA VLRQASVDAC ELTPTVAASL LRKRENAPQL KLLLTIGEML NPLVVKEFGG
TTDRGSILWA MYGPTEATIH CTLQGDFQSN YSTGNIGIPP ETVSCFIIKP AADDYDPTSF
DLLPAGDVGE LAVGGHQLAS GYLNDELKTN KAFIESPYGR VYRTGDKAKM NQDGTLECLG
RISDGQVKLR GQRIELGEIE HAAMKTSGCH GAAARVIGGI LVLFCAVDAC VSEVDILQSC
SQWLPQFMIP GDVVLSEELP RLPSGKVNAK ELQRQFEQSK AQEGQSADLK KSTEPELLQV
LQDCFGSQLS LQTELARAGL DSLTAIGLSS DLRDAGYDVR AVSLLKMKTI GHLVSSIKII
DEADGDNEGT RTSVSCLEKL AELKSKELKL EMSYRNVQDI IPCTNLQIAM LSESIRNPGA
YWNAVDLELS TTAAAEDICR AIHAIVEQNE ILRTGFVQHD STIYSVIFDA INSDCVRIAD
EMELVPPKKS NPDLLRPLQI RIKKGAKGNS YNMQVHLHHA IYDGWSLDLF KSDLARAIGS
EGLPSRNQFR DMVAFSLSQK REQYDEKARV FWADYLFGWN KPPFPRLIPR AVPCGTIQSK
TYRHSLPSSA NQAYNGSAQV PFQAALSLVW GGILGLQDVV IGSVTSGRTI PVKGVENIMG
PCISSLPLRV NMERMNTIDD LVNSISSSNR HMMEHSTLSQ LAVKKSINMY GAEQLYDVLF
VYQESLEQRK QTGSIVQEIA HLDRLETKLV LEVQPIQDAV VLQATFHDDY FSSESVEKIL
SQVAEISSAI LENPHSLLES MRSMETDVST YNMKLEKMDR DSQPDNLAGV VERAATRFGD
RTAVSFATQS SATTMEATNI TYTDLNRNAN CIAHFLLSQK VQSGEVIPII MNKSIRLYTT
ILGIIKAGCG YLPLLPSTPN ARILEIFNQS GSRLCLADED SISNIPPSTT VRTILIDEES
MEDYPVENPS IDINSSNTAY VIYTSGTTGT PKGVTVSHKN IASNVTYLGV EYPDSAKASS
NFLQACSQAF DVSVFEIFFA WHKGMCLCAA SNDVLFADIE EAIRQFEITH LSLTPTIASL
IDPSNVPSVE FLVTAGEPMT NAVSERWNKY LWQGYGPSET TNICSVKKMS SDDYIEHLGL
VFNNTSVAVL QPKGLSTLPI GWAGEFCFGG DQVATGYLNM PRLTAEKFIQ HPKYSRLYRS
GDFGRMLPDG SLVILGRIDD QVKLRGQRIE AAEINGIVSR VSSATAAVTL VLKQIDSMGE
WLVTFYVQDK DAEDFRILEP NASAHHQIFA ELHAKLLSYM VPSYLIPVSR IPLTSSGKVD
KRAINTTFTQ LSKDYLKTVA HNSVKEDDED WNDTEQAIAS LIAASLKISR NDIGRWTPLA
ILGLDSLSAI QVSRSLTNEF RTTVSISCIL QHPTIAQLAR KLHSSHESGD VAIVNDFFSQ
EFQQSVTAVL AEENKEVVEI LPCSPLQEAM VSRGKTSYYN KSLLRLHIDP YKMRGYWQHM
CERHSILRTC FMATNSSSYP IAQVSLAKWE LPWHEFTVTQ PSLEDAIRDH LALVPEPLET
NTPPLSLALI RYGEIRFLSF ICHHALYDGV AMECLWREVE SLARGEQLRP SVAQGPFISE
IMKLPSTSQT FWKQQFSNFQ PSVLFRKPNG KAVQQATHSL TVERSLHKTQ HQIKSLGISL
LALCQATMAR LLAVVSQKSD VCFGNVMNGR TIGLEGIERL VAPCFNTVPI RQDMPDTLSN
IDLAKSLLAL NTSMLEHQFT PLRQVQKIAA TERRSLFDSL LLVQQPLQEM DVNVWTLEED
AGVMDLPLVC EITPCPNLNT LVLDVHYDMS AVPHVAAAGI ASLFEHILLQ ILESPHAVLA
RRSIPEPLLE QVHLRQPFFF DDSEDQYETE DSDSSWTDEE LAVRAVLSEL SQTPTQRIDR
TTSLFKLGLD SINAVQVAAI LRQKDYSISA SDIVECQNCS KIARRIFENG YQPKKEIELH
DFAAFDVQVR PELDIAGNGY RLLPCTPMQS AMLSAYVSSN GVHYLNEISL EMDKEITAPL
VAEKWAQLVA VHAMLRTGFA SVRHADSAYA MIQYESVQSE RFIHVDNGGF KPRDWKASEA
NSIQKSWNLP PWRLGVTTKN GAVNVYLIIH HALYDATSLQ ELLSNFGRLL NSNKTLPVED
VDTGLSAVLH RTAGEQEEAS AFWRQLGEQA TINRFPLLTP LREANREILI EEMTSTLTSP
DLHQMTKSLE ISVQTAILAS WSRLLAAYTG EEAVIFGVTF SGRSCEATLG TPVPCLTTVP
VVAQNLGSNR DLLSQMMRTA SDIYQHQYLP LNRIQKEMGY PATALFDTLV AYQKIESEAN
DRPWVQKQDD AAAEFPVSLE VEPRDDDSIC LRITYFSDIL PSDQAKLLLR QFDATMEDLL
VNPDGHQHDL HNYHPDIFAI SPPLEPTMNA PVELLHQFVE VQAKLNPDKI ALEHVSGFRG
KEPIRDQWTF AQLNSIGNKV ANMLSSRTEA GSIIAIHFDK CPEAYFAILG ILKSGSAFVA
LDFSAPSARK QFILQDSRAP CLLTSEDNVI EFEVPCPVIV IDNALLSDYA ETPCEVNNTL
TPSSTCYCLY TSGTTGTPKG CEITHENTVQ CMMAFQDLFH GHWADDSRWL QFAALHFDVS
VLEQYWSWSA GITVVSAKKD LILDDLIGFI NNANITHIDL TPSLARLTHP ETVPGLCRGV
FITGGEQLKQ EILDAWGSKA VIYNAYGPTE ATIGVTTYQR VPQNGRPSNI GRQFRNVGSY
VFHKDTEIPV LRGGVGELCI SGKLVGKGYL NRPQLTDEKF PTLESFGERI YRTGDLVRIL
HDGCFEFLGR ADDQVKLRGQ RLELGEIDHV IRSVKNIHDV TTLVTKHTSS GKDVLVSFIV
EEKIPDTPLV VLADNSSIST DARNMCRDKL PSYMVPSYFL KLPYIPLSPN NKAEAKLLKK
LFSELSQEDL IKFGSAAVKR DLSKDSAGYQ KLISSLAQFC NLDTATIEDS ASVFDFGVDS
ITALSLSAFL VEKGMFAASP ALILRNPIVA DLAVALSTAS SHDTSAEVKR TRQRVQAFEH
KYKARVCRDL GAPPSDIEYI YPCSPLQQGM LAKTAVEDGE GAYFNVFKFH LKPGAVVSSV
RAALNKLFEQ EPILRTTFLH TPDGYVQVAR RGISLPWNEC SLAEDGRIEE VVESLWHAWV
KENSDRVHTP IKATFVTDTD VNMIVLHIFH GLYDGTSFDL MMTRLTNLCN NVEAKAGPSF
ADALIHGPLR NHDESKQAWI EHLKGWSLSL LALPKEEKSV RPISHTRVLS ASKLEALRSI
KNVTMQSLLL AAWVSTLQKH SHGNATTGVI ISGRSIAMPG VEETIGPLFN TLPFFANFSS
APTWHSLLQR CQDFNATVLE DPHVPLQQLQ KWISNGKPLF ESLFAYQIED RRNQRDDLPW
IVEDGGLNPD YSLALEVTKR GDDTMQLLLV AKNDLASETV LKNILDVFED MLASVETDAA
IPVQVETALV DALKSEQVKT IKENVEEVWG PAADVLRREV AALANISEAE IAPSTTWLEL
GLDSIDAVQF SARLKRHHMI ISPSAIMKGW SMAYLSSLVM RLTNGDASCE LDNLREIKSK
LRRYVEATGF DMTEADDILP TTPLQDAMVS GMIESDFTWY FNHEVLKVAP GVDVDKLQAA
WSRLFDMTPI LRTGFVELVD PQASAVYAQV VYNSSPVISD VTVTSLEELQ AIQEQSRAHA
SQGGAKRNLA RVVRAQLGET TFFVLSISHA LYDGWSLGLL HQDLKSLYYG ESVGRPSPDQ
FLFKSNASLT PEAQGFWTNY LEKARPTIIP QVEPDSSSVV KAEGFSSTTL SDISRFCREQ
KISLQSLCQA CWAIILARTT RSLDVVFGSI LSGRDFDGAE DLLFPTMNTV AVRCILHGSI
SSFLHYMEDN LGELRSYQMV PLRKATTAAK AAGKDLFNSL FLLQKTPAES SSGSLFQSVE
GSSGVDYPVC VEAAASGEVL EWTVACQGQS RDGRYAKELL AELHTTLDYV LRHAEEDVVS
FSRAGTRICG SQPIALAEDD DEIPQIDKYT SYEWNATSLA IRKVLSQVSN IPADAIDASS
TLYHLGLDSI TAIKVSTLLK QRGIFLRPTQ LVRSSSIAHM AEQVAALGSF EPPQTNLSWQ
AWTPPKNADA DGILSEAGIL KGQVEHVLPA LPMQVYMMSI WQNTNGNIFY PEFTYKLSGP
HTATDVRNAW ARVVEQLPML RTCLFATGQQ DLPFIQVILK PGMSHAGVQP FVRIEIDQTP
GSPETLLRLR IHHALYDGVS LPAITDTLLH HLKGDASRDA APIHQWAHTV TARHDEAHMA
SRKAFWTQYL DGCSDASRPD NDMTGSRTSL FQEGAFSCAS ALTDLAARNG ISLQSLVLAA
YALSLPHTGQ DVVLGVYLAG RADDRVPDTL PTLNLVPLRI KARHRDDHVL EMARRVHEDM
QKITADDAAG NAQVGLWEVA RWTGVKIDRF VNFLTLPAAA AAGKDESNVS LHLAPTSNPV
KEDEAAMTTC IHDAAKNAVR DYYPDSVDVE FAVRNGHLDM GVFGPQTRIT DEGAHELVRS
VVQRLKKTVE ACVH
//
