ID J4TLM4_9MYCO Unreviewed; 450 AA.
AC J4TLM4;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=3-oxoacid CoA-transferase {ECO:0000256|ARBA:ARBA00012490};
DE EC=2.8.3.5 {ECO:0000256|ARBA:ARBA00012490};
GN ORFNames=MCOL_V201550 {ECO:0000313|EMBL:EJO90873.1};
OS Mycobacterium colombiense CECT 3035.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium avium complex (MAC).
OX NCBI_TaxID=1041522 {ECO:0000313|EMBL:EJO90873.1, ECO:0000313|Proteomes:UP000006455};
RN [1] {ECO:0000313|EMBL:EJO90873.1, ECO:0000313|Proteomes:UP000006455}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 3035 {ECO:0000313|EMBL:EJO90873.1,
RC ECO:0000313|Proteomes:UP000006455};
RX PubMed=21952541; DOI=10.1128/JB.05928-11;
RA Gonzalez-Perez M., Murcia M.I., Landsman D., Jordan I.K.,
RA Marino-Ramirez L.;
RT "Genome sequence of the Mycobacterium colombiense type strain, CECT 3035.";
RL J. Bacteriol. 193:5866-5867(2011).
CC -!- PATHWAY: Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA
CC from succinyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004753}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase family.
CC {ECO:0000256|ARBA:ARBA00007154, ECO:0000256|PIRNR:PIRNR000858}.
CC -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit A family.
CC {ECO:0000256|ARBA:ARBA00005612}.
CC -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit B family.
CC {ECO:0000256|ARBA:ARBA00007047}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJO90873.1}.
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DR EMBL; AFVW02000001; EJO90873.1; -; Genomic_DNA.
DR RefSeq; WP_007768567.1; NZ_CP020821.1.
DR AlphaFoldDB; J4TLM4; -.
DR STRING; 1041522.GCA_002105755_04402; -.
DR GeneID; 78828376; -.
DR eggNOG; COG1788; Bacteria.
DR eggNOG; COG2057; Bacteria.
DR OrthoDB; 9778604at2; -.
DR UniPathway; UPA00929; UER00894.
DR Proteomes; UP000006455; Unassembled WGS sequence.
DR GO; GO:0008260; F:succinyl-CoA:3-oxo-acid CoA-transferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046952; P:ketone body catabolic process; IEA:InterPro.
DR Gene3D; 3.40.1080.10; Glutaconate Coenzyme A-transferase; 2.
DR InterPro; IPR012792; 3-oxoacid_CoA-transf_A.
DR InterPro; IPR012791; 3-oxoacid_CoA-transf_B.
DR InterPro; IPR014388; 3-oxoacid_CoA-transferase.
DR InterPro; IPR004165; CoA_trans_fam_I.
DR InterPro; IPR004164; CoA_transf_AS.
DR InterPro; IPR004163; CoA_transf_BS.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR NCBIfam; TIGR02429; pcaI_scoA_fam; 1.
DR NCBIfam; TIGR02428; pcaJ_scoB_fam; 1.
DR PANTHER; PTHR13707; KETOACID-COENZYME A TRANSFERASE; 1.
DR PANTHER; PTHR13707:SF23; SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE; 1.
DR Pfam; PF01144; CoA_trans; 2.
DR PIRSF; PIRSF000858; SCOT-t; 1.
DR SMART; SM00882; CoA_trans; 2.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 2.
DR PROSITE; PS01273; COA_TRANSF_1; 1.
DR PROSITE; PS01274; COA_TRANSF_2; 1.
PE 3: Inferred from homology;
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000858};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT ACT_SITE 285
FT /note="5-glutamyl coenzyme A thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000858-1"
SQ SEQUENCE 450 AA; 47633 MW; 781FD57DAC5AE9C6 CRC64;
MSNKVHHDAE SALDGLLKDG ITIAAGGFGL CGIPEKLIQA LVDSGIKDLT IVGNNAGVDD
FGMGLLLKGR QVNKVIASYV GENKEFERQV LSGELDLVLT PQGTLAEKLR AGGAGIPGFY
TRTAFGTNLA EGKDTRVFDG TEYVLEEGIR ADVAIVKAWK GDTAGNLVYR KTARNFNPMI
ATCGAITVAE VEELVEVGEL DPDLIHTPGI YVDRIIEGTG YEKRIEFRTT SGGAALKSDS
PVRERMAQRA ARELRDGFYV NLGIGIPTLV ANFIPDGIKV TLQSENGLLG IGAYPSEDAI
DPDLINAGKQ TITSLPGSSF FSSADSFAMI RGGHIDLSIL GALEVAENGD LANWMVPGKM
VKGPGGAMDL VSGVKRVIVL MDHTAKDGSP KVLSQCSLPL TGKNVVDMII TNLCVFDVEP
GQGLVLTELQ PGVTVEEVRA KTGCDFKVAV
//
