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Database: UniProt
Entry: J4WC17_9FIRM
LinkDB: J4WC17_9FIRM
Original site: J4WC17_9FIRM 
ID   J4WC17_9FIRM            Unreviewed;       449 AA.
AC   J4WC17;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EJU23071.1};
GN   ORFNames=HMPREF1152_1804 {ECO:0000313|EMBL:EJU23071.1};
OS   Mogibacterium sp. CM50.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales;
OC   Clostridiales Family XIII. Incertae Sedis; Mogibacterium.
OX   NCBI_TaxID=936375 {ECO:0000313|EMBL:EJU23071.1, ECO:0000313|Proteomes:UP000003142};
RN   [1] {ECO:0000313|EMBL:EJU23071.1, ECO:0000313|Proteomes:UP000003142}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM50 {ECO:0000313|EMBL:EJU23071.1,
RC   ECO:0000313|Proteomes:UP000003142};
RA   Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B.,
RA   Sutton G., Nelson K.E.;
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EJU23071.1}.
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DR   EMBL; ALNL01000012; EJU23071.1; -; Genomic_DNA.
DR   RefSeq; WP_009643401.1; NZ_ALNL01000012.1.
DR   EnsemblBacteria; EJU23071; EJU23071; HMPREF1152_1804.
DR   PATRIC; fig|936375.3.peg.379; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000003142; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003142};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003142}.
FT   DOMAIN      140    274       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      354    423       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     148    155       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   449 AA;  51963 MW;  B06E9CBEAA1950ED CRC64;
     MDTNKIWESF IEEIKKSTSR LSFDMFFSDL SLYKLDLDNK IIYIQLEDIS IIKFLREKYI
     INIEDIFLKL LGDDFQVIIK SKEEYKSNKI EKKRKIKKAP FKDNSKLFNP RYNFENFVVG
     GNNKFAYAAS LAVAESPAEA YNPLFLYGGS GLGKTHLMQA IGIHVIKNDP SSNVLYISSE
     TFTNELIEAI NTQNTNQFKE KYRKIDVLLI DDIQFLEGKE ATQEEFFHTF NTLYENNKQI
     VISSDRPPSN LQKLDERLTT RFGFGITADV QPADFETRVA ILKKKIELAD ITLDRDIEEV
     CNLIAEKIKY NIRELEGAMN RMISFSEIMN NKIDLDFAKI VLKDIYRDTD KAIAPERIRS
     TVASHYDIKV SDIDSKRRTA EIALARQVAM YICRESTDLS FSKIGEIFGG RDHSTVMSNC
     TKIQNLYQED ELIKRDIDDI NKKLNKHNL
//
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