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Database: UniProt
Entry: J4WPL3_9GAMM
LinkDB: J4WPL3_9GAMM
Original site: J4WPL3_9GAMM 
ID   J4WPL3_9GAMM            Unreviewed;       431 AA.
AC   J4WPL3;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   05-JUL-2017, entry version 31.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EJP71350.1};
GN   ORFNames=NT01SARS_1157 {ECO:0000313|EMBL:EJP71350.1};
OS   SAR86 cluster bacterium SAR86A.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; SAR86 cluster.
OX   NCBI_TaxID=1123866 {ECO:0000313|EMBL:EJP71350.1, ECO:0000313|Proteomes:UP000010305};
RN   [1] {ECO:0000313|EMBL:EJP71350.1, ECO:0000313|Proteomes:UP000010305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22170421; DOI=10.1038/ismej.2011.189;
RA   Dupont C.L., Rusch D.B., Yooseph S., Lombardo M.J., Richter R.A.,
RA   Valas R., Novotny M., Yee-Greenbaum J., Selengut J.D., Haft D.H.,
RA   Halpern A.L., Lasken R.S., Nealson K., Friedman R., Venter J.C.;
RT   "Genomic insights to SAR86, an abundant and uncultivated marine
RT   bacterial lineage.";
RL   ISME J. 6:1186-1199(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; JH611157; EJP71350.1; -; Genomic_DNA.
DR   Proteomes; UP000010305; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010305};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010305}.
FT   DOMAIN      128    259       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      339    408       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     136    143       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      290    317       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   431 AA;  49129 MW;  B5C2596BE63A46A7 CRC64;
     MELWNKCSEK LENTLSQEDF NTWIRPLKAS QEKNTLELVA PNDFILNYIE KNFAKEIKTL
     VKSNSKKNIN LVFKTLTKET FVDKYQNTSK NAEIKLVDGY TFDNFVEGKS NHLALAAAKQ
     VAANPKGDYN PLFIYGGVGL GKTHLMHAVG NQILKNEPKK RIVYVHSEKF VSDMVKALQL
     GAMNEFKSFY RNADALLIDD IQFFAGKEQS QEEFFHTFNA LLDRNNQMIL TCDKYPKEID
     GLEERLKSRL GWGLPVVIDP PELETRAAVL LNKANTMGVV LPNDCAIYIA QRIRSNIREL
     EGALKRVVAN ARFTNQEIDL ALVKDALKDL FVISAKMVSI ENIQKTVAEY YNIKLSDLLS
     KRRSRSITRP RQMAMALTKQ LTNHSLPEIG EAFNGRDHTT VLHACKKITD LRKESPSHEE
     DYRNLNRALT N
//
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