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Database: UniProt
Entry: J4X8X1_9ACTN
LinkDB: J4X8X1_9ACTN
Original site: J4X8X1_9ACTN 
ID   J4X8X1_9ACTN            Unreviewed;       519 AA.
AC   J4X8X1;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-SEP-2017, entry version 36.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EJU31956.1};
GN   ORFNames=HMPREF1155_1579 {ECO:0000313|EMBL:EJU31956.1};
OS   Slackia sp. CM382.
OC   Bacteria; Actinobacteria; Coriobacteriia; Eggerthellales;
OC   Eggerthellaceae; Slackia.
OX   NCBI_TaxID=1111137 {ECO:0000313|EMBL:EJU31956.1, ECO:0000313|Proteomes:UP000004399};
RN   [1] {ECO:0000313|EMBL:EJU31956.1, ECO:0000313|Proteomes:UP000004399}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CM382 {ECO:0000313|EMBL:EJU31956.1,
RC   ECO:0000313|Proteomes:UP000004399};
RA   Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B.,
RA   Sutton G., Nelson K.E.;
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EJU31956.1}.
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DR   EMBL; ALNO01000019; EJU31956.1; -; Genomic_DNA.
DR   RefSeq; WP_009079293.1; NZ_ALNO01000019.1.
DR   EnsemblBacteria; EJU31956; EJU31956; HMPREF1155_1579.
DR   PATRIC; fig|1111137.3.peg.1655; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004399; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004399};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004399}.
FT   DOMAIN      202    379       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      426    495       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     210    217       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   519 AA;  57916 MW;  B531ABFC4EB2E824 CRC64;
     MTSTELFETW INVLTLMKSY EDVSGMQMDA FFSRVHPQAT SEGFLIATAE TNFIKEQVEK
     RYSNAMKRAL KELTGMDYLI EIEVDESFIA SAAQVRLQSS GDAIPSHTEQ TPPSPASQPH
     PSTAGTDTQI SEPPLDRSRS IPSNHKETAA EAAADPSPMK GSGSYSGIVS SLTFENYVIG
     DSNRLAYSMA LAVAEQPGVK PMLNPLFIYG NSGLGKTHLL RAIQNYINAT YPTMDAVYVD
     SSEFLNDYTA AVASHDKDKK SYQDFQNRYW NADVLIIDDV QFFQGKSATV DIVFQLLNKL
     IDRGKQVVLS ADRAPKTIDV DERMQSRFNQ GGTFDIQPPE VETKLGIIKS FIAEHRRASG
     EDTASIPKDV QMYIAENSSS NVRELKSAVT RVLSEIIYKG RKDFSVEDAQ ELLADHFSSG
     ATKKADVATI QHVVEQYYKV SHADLVGVKR SRNIVYARQI AIYLSRNMLD VPFASIGKKF
     GQRDHSTIMH SVKAVEDKMR KDKEIRDEIE IITKMIREN
//
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