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Database: UniProt
Entry: J5KCD4_9GAMM
LinkDB: J5KCD4_9GAMM
Original site: J5KCD4_9GAMM 
ID   J5KCD4_9GAMM            Unreviewed;       431 AA.
AC   J5KCD4;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   05-JUL-2017, entry version 33.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EJP72793.1};
GN   ORFNames=NT02SARS_1514 {ECO:0000313|EMBL:EJP72793.1};
OS   SAR86 cluster bacterium SAR86B.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; SAR86 cluster.
OX   NCBI_TaxID=1123867 {ECO:0000313|EMBL:EJP72793.1, ECO:0000313|Proteomes:UP000010116};
RN   [1] {ECO:0000313|EMBL:EJP72793.1, ECO:0000313|Proteomes:UP000010116}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22170421; DOI=10.1038/ismej.2011.189;
RA   Dupont C.L., Rusch D.B., Yooseph S., Lombardo M.J., Richter R.A.,
RA   Valas R., Novotny M., Yee-Greenbaum J., Selengut J.D., Haft D.H.,
RA   Halpern A.L., Lasken R.S., Nealson K., Friedman R., Venter J.C.;
RT   "Genomic insights to SAR86, an abundant and uncultivated marine
RT   bacterial lineage.";
RL   ISME J. 6:1186-1199(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; JH611186; EJP72793.1; -; Genomic_DNA.
DR   Proteomes; UP000010116; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000010116};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000010116}.
FT   DOMAIN      128    256       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      339    408       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     136    143       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   431 AA;  49180 MW;  70F2D4C1F7CE7AB0 CRC64;
     MEFWNKCSEK LENKLSQEDF NTWIRPLKGN LNKNILEIVA PNDFILNYVE SNLAKNIKEI
     ISTQSKKDIS LVFKTHTKET FVDKYKNNAK SEDTKLVPSY VFDNFVEGKS NHVALAASKQ
     VASNPRGDYN PLFIYGGVGL GKTHLMHAVG NEILKNEPNK RIVYVHSEKF VSDMVKALQL
     GAMNEFKSFY RNADALLIDD IQFFAGKEQS QEEFFHTFNA LLDRNNQMIL TCDKYPKEID
     GLEERLKSRL GWGLPVIIEP PELETRAAVL LQKASTMGVE LPNDCAIYIA QRIRSNIREL
     EGALKRVVAN ARFTNQDIDL ALVKDALKDL FVISAKMVSI ENIQKTVAEY YNIKLSDLLS
     KRRSRSITRP RQLAMALTKE LTRHSLPEIG EAFNGRDHTT VLHACKKIAE LRKESPSHEE
     DYRNLTRALT N
//
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