ID J6EFY6_SACK1 Unreviewed; 745 AA.
AC J6EFY6;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Spindle assembly checkpoint component MAD1 {ECO:0000256|ARBA:ARBA00022019};
DE AltName: Full=Mitotic arrest deficient protein 1 {ECO:0000256|ARBA:ARBA00032890};
GN Name=YGL086W {ECO:0000313|EMBL:EJT42422.1};
GN ORFNames=SKUD_180803 {ECO:0000313|EMBL:EJT42422.1};
OS Saccharomyces kudriavzevii (strain ATCC MYA-4449 / AS 2.2408 / CBS 8840 /
OS NBRC 1802 / NCYC 2889) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=226230 {ECO:0000313|EMBL:EJT42422.1, ECO:0000313|Proteomes:UP000002753};
RN [1] {ECO:0000313|EMBL:EJT42422.1, ECO:0000313|Proteomes:UP000002753}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889
RC {ECO:0000313|Proteomes:UP000002753};
RX PubMed=12775844; DOI=10.1126/science.1084337;
RA Cliften P.F., Sudarsanam P., Desikan A., Fulton L., Fulton B., Majors J.,
RA Waterston R., Cohen B.A., Johnston M.;
RT "Finding functional features in Saccharomyces genomes by phylogenetic
RT footprinting.";
RL Science 301:71-76(2003).
RN [2] {ECO:0000313|Proteomes:UP000002753}
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4449 / AS 2.2408 / CBS 8840 / NBRC 1802 / NCYC 2889
RC {ECO:0000313|Proteomes:UP000002753};
RX PubMed=22384314; DOI=10.1534/g3.111.000273;
RA Scannell D.R., Zill O.A., Rokas A., Payen C., Dunham M.J., Eisen M.B.,
RA Rine J., Johnston M., Hittinger C.T.;
RT "The awesome power of yeast evolutionary genetics: New genome sequences and
RT strain resources for the Saccharomyces sensu stricto genus.";
RL G3 (Bethesda) 1:11-25(2011).
CC -!- SIMILARITY: Belongs to the MAD1 family.
CC {ECO:0000256|ARBA:ARBA00008029}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJT42422.1}.
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DR EMBL; AACI03001467; EJT42422.1; -; Genomic_DNA.
DR AlphaFoldDB; J6EFY6; -.
DR STRING; 226230.J6EFY6; -.
DR HOGENOM; CLU_026595_0_0_1; -.
DR Proteomes; UP000002753; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IEA:InterPro.
DR Gene3D; 3.30.457.60; -; 1.
DR InterPro; IPR008672; Mad1.
DR PANTHER; PTHR23168:SF0; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1; 1.
DR PANTHER; PTHR23168; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1; 1.
DR Pfam; PF05557; MAD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002753}.
FT REGION 43..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 113..165
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 191..225
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 256..317
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 400..441
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 537..571
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 335..364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 86841 MW; 7817333E9424FB8B CRC64;
MAALNSSLAA LIDSLYTPVT LFIGGFKPEV CCIRYKMSNS GGSSPFLESP GGSRDMGSNS
EQSNRQVQAL QFKLNTIQNE YEIDRLQLQK QTNILEKKYK ATIGELEKSL NDTKYLYENN
AKLEQELQSL KETSTKSTTD KDKFIQELQI TLQNNDLEMD ALKQQYDSKL SKLTNQCNHF
KLEADSSRSL LLKYENEVKR QSVDIKDLQH QVMEKDDDLS SLKASKMMNS HPNYSTEEFN
ELTEMNKMIH DQVQYTKELE LANMQQANEL KKLKQSQDSS TFWKLENEKL QNKLKQLHTL
ENQYENLQLE NIDLKSKLTN WEIYNDDDDD DNGNHNNNNN NNNDGYNNND GNKNSDCTNK
AKNNLQSGPE EIIRDWKLTK KECLVLTDKN DKLRLDNNNL KLLNDEMALE RNQILDLNKS
YENSIVNLKR LNHELEQQKS LSFEECRLLR EQLDDLYSAQ SITSSETISN EKNALKANVS
ESVNNLLNTY KNKTEDLTSE LKKLNDQLLS NSNDVETQRK KRKLTSDQIG LNYSQRLNEL
QLENVKISRE LSKAQGTIQL LQEKLEKLTK FKEKRVRILQ LRDGPFIKDQ FIKKSKLRLL
EKENSDLLNE LKQNNPNSET IPISVYDSLN FELQQFEQEV FRSNKRFFRL KQVFNRKSLE
FIDVVNSLLG FKLEFQQDGR VKIFSCFKPE KYLIADLNEN TLKSNLDANI DNWDDLMNLW
VEDRGQLPCF LATITLRLWE QQQAK
//
