ID J7CXF9_ENTFC Unreviewed; 387 AA.
AC J7CXF9;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Regulatory protein MsrR {ECO:0000256|ARBA:ARBA00040752};
GN ORFNames=HMPREF1348_00361 {ECO:0000313|EMBL:EJY47445.1};
OS Enterococcus faecium 505.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=1134806 {ECO:0000313|EMBL:EJY47445.1, ECO:0000313|Proteomes:UP000006403};
RN [1] {ECO:0000313|EMBL:EJY47445.1, ECO:0000313|Proteomes:UP000006403}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=505 {ECO:0000313|EMBL:EJY47445.1,
RC ECO:0000313|Proteomes:UP000006403};
RA Weinstock G., Sodergren E., Lobos E.A., Fulton L., Fulton R., Courtney L.,
RA Fronick C., O'Laughlin M., Godfrey J., Wilson R.M., Miner T., Farmer C.,
RA Delehaunty K., Cordes M., Minx P., Tomlinson C., Chen J., Wollam A.,
RA Pepin K.H., Bhonagiri V., Zhang X., Suruliraj S., Warren W., Mitreva M.,
RA Mardis E.R., Wilson R.K.;
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in SarA attenuation. Affects resistance to oxacillin
CC and teicoplanin, as well as the synthesis of virulence factors.
CC {ECO:0000256|ARBA:ARBA00037178}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC -!- SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family.
CC {ECO:0000256|ARBA:ARBA00006068}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJY47445.1}.
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DR EMBL; AMBL01000012; EJY47445.1; -; Genomic_DNA.
DR RefSeq; WP_002400183.1; NZ_JH813135.1.
DR AlphaFoldDB; J7CXF9; -.
DR PATRIC; fig|1134806.3.peg.343; -.
DR HOGENOM; CLU_016455_1_0_9; -.
DR Proteomes; UP000006403; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.630.190; LCP protein; 1.
DR InterPro; IPR004474; LytR_CpsA_psr.
DR NCBIfam; TIGR00350; lytR_cpsA_psr; 1.
DR PANTHER; PTHR33392; POLYISOPRENYL-TEICHOIC ACID--PEPTIDOGLYCAN TEICHOIC ACID TRANSFERASE TAGU; 1.
DR PANTHER; PTHR33392:SF8; REGULATORY PROTEIN MSRR; 1.
DR Pfam; PF03816; LytR_cpsA_psr; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 99..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 162..305
FT /note="Cell envelope-related transcriptional attenuator"
FT /evidence="ECO:0000259|Pfam:PF03816"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 44129 MW; 61DFB00C817CF8C7 CRC64;
MSRMDRYKDI HKKAKPLKRD TGSIFARRER KQTRMENEED ATRIYEREQH SFEHLNQHEQ
QIYRDAPRAE EQQKNKKFFN RQKKNKPLKP RRKQSWKKII LSILLVLILY SGISFFIGKY
VAEHDTSLEA ATSETFHGQK ATNGAHNILI LGSDTRGEDA GRADTIMVLQ LDGPSHKPKL
ISFMRDSFVT IPGVGQNKIN SAYAYGGANL VRQTLVENFG IDCQYYAKVD FKSFEKVIDA
LFMNGVKIDA EKDLNLDGVD IKKGIQKMDG HVLLQYARFR MDEEGDFGRV RRQQQVMNAI
FSQLKNPLNL IRAPYAAGKA LGYTSTDVTA WFLTKNLFSI ARGAGGIDRI SVPVDGSWNY
GQSDYAGSIL EIDNQMNQSA ITDFLNK
//
