ID J7ETQ9_9VIRU Unreviewed; 3945 AA.
AC J7ETQ9;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=RNA-directed RNA polymerase L {ECO:0000256|ARBA:ARBA00018602};
DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
DE AltName: Full=Large structural protein {ECO:0000256|ARBA:ARBA00030285};
DE AltName: Full=Replicase {ECO:0000256|ARBA:ARBA00031012};
DE AltName: Full=Transcriptase {ECO:0000256|ARBA:ARBA00030436};
OS Orthonairovirus haemorrhagiae.
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Ellioviricetes; Bunyavirales; Nairoviridae; Orthonairovirus.
OX NCBI_TaxID=3052518 {ECO:0000313|EMBL:AEO72047.1, ECO:0000313|Proteomes:UP000150033};
RN [1] {ECO:0000313|EMBL:AEO72047.1, ECO:0000313|Proteomes:UP000150033}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIV 11703 {ECO:0000313|Proteomes:UP000150033};
RX PubMed=23195573; DOI=10.1016/j.meegid.2012.10.005;
RA Yadav P.D., Cherian S.S., Zawar D., Kokate P., Gunjikar R., Jadhav S.,
RA Mishra A.C., Mourya D.T.;
RT "Genetic characterization and molecular clock analyses of the Crimean-Congo
RT hemorrhagic fever virus from human and ticks in India, 2010-2011.";
RL Infect. Genet. Evol. 14:223-231(2013).
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DR EMBL; JN627865; AEO72047.1; -; Viral_cRNA.
DR Proteomes; UP000150033; Genome.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd21880; OTU_RNAP_L_virus; 1.
DR Gene3D; 3.90.70.80; -; 1.
DR InterPro; IPR049605; L_OTU.
DR InterPro; IPR003323; OTU_dom.
DR InterPro; IPR015843; RNA-dir_pol_nairovirus.
DR InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR InterPro; IPR007322; RNA_pol_bunyavir.
DR Pfam; PF04196; Bunya_RdRp; 1.
DR Pfam; PF02338; OTU; 1.
DR PIRSF; PIRSF036900; RdRPol_NRV; 1.
DR PROSITE; PS50802; OTU; 1.
DR PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE 4: Predicted;
FT DOMAIN 29..158
FT /note="OTU"
FT /evidence="ECO:0000259|PROSITE:PS50802"
FT DOMAIN 2342..2551
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50525"
FT REGION 762..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2717..2745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..776
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 40
FT /note="For ubiquitin thioesterase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR036900-50"
FT ACT_SITE 151
FT /note="For ubiquitin thioesterase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR036900-50"
SQ SEQUENCE 3945 AA; 447970 MW; ABFF14207474CB6A CRC64;
MDFLRNLDWT QVIDGQYVTN PRFNISDYFE IVRQPGDGNC FYHSIAELTM PNKTDYSYHN
IKHLTEVAAR KYYQEEPEAK LIGLSLEDYL TRMLSDNEWG STLEASMLAK EMGVTIIIWT
VAASDEVEAG IKFGDGDVFT AVNLLHSGQT HFDALRILPQ FETDTRETLS LVDKVIAVDQ
LTSSSSDELQ DYEDLALALT SAEEPYRRSS LDEVTLSKKQ AEVLRQKASQ LSKLVNKSQN
IPTRVGRVLD CMFNCKLCVE ISADTLILRP ESKERIGEVM SLRQLGHKLL TRDKQIKQEF
SKMKLYVTKD LLDHLDVGGL LRAAFPGTGI ERHMQLLHSE MILDICTVSL GVMLSTFLYG
SNNKNKKKFI TNCLLSTALS GKKVYKVLGN LGNELLYKAP RKALATVCSA LFGEQINKLQ
NCFRTISPVS LLALRNLDFD CLSVQDYNGM IENMSKLDNT DVEFNHREIA DLNQLTSRLI
TLRKEKDTDL LKQWFPEGDL TRRSTRNVAN AEEFVISEFF KKKDIMKFIS TSGRAMSAGK
IGNVLSYAHN LYLSKSSLNM TSEDISQLLI EIKRLYALQE DSEVEPIAII CDGIESNMKQ
LFAILPPDCA RECEVLFDDI RNSPTHSTAW KHALRLKGTA YEGLFANCYG WQYIPEDIKP
SLTMLIQTLF PDKFEDFLDR TQLHPEFRDL TPDFSLTQKI HFKKNQIPSV ENVQISIDAT
LPESVEAVPV TERKMFPLPE TPLSEVHSIE RIMENFTRLM HEGKSSTKKK DEDPTGQDSQ
QSAAEHEGPS ILAFKDYGER GIVEENHMRF SEEDQLETRQ LLLVEVGFQT DIDGKIRTDH
KKWKDILKLL ELLGIKCSFI ACADCSSTPP DRWWITEDRV RVLKNSVSFL FNKLSRNSPT
EVTDIVVGAI STQKVRSYLK AGTATKTPVS TKDVLETWER MKEHILNRPT GLTLPTSLEQ
AMRKGLVEGV VISKEGSESC INMLKENLDR ITDEFERTKF KHELTQNVTT GEKMLLSWLS
EDIKSSRCSE CLANIKKTVD ETANLSEKIE LLAYNLQLAS HCSNCHPNGV NISNISNVHK
RCPKIEVVSH CENKGFEDSN ECLTDLDRLV RLTLPGKTEK ERRVKRNVEY LIKLMMSMSG
IDCIKYPTGQ LITHGRVSAK HNDGNLKDRS DDDQRLVEKI DTVRKELSET KLKDYSAYAR
GVISNSLKNL SKQGKSKCSV PRSWLEKILF DLKVPTKDEE VLINIRNSLK ARSEFVRNND
KLLIRSKEEL KKCFDVQSFK LMKNKQPVPF QVDCILFKEV AAECMKRYIG TPYEGIIDTL
VSLINVLTRF TWFQEVVLYG KICETFLRCC TEFNRSGVKL VKVRHCDINL SVKLPSNKKE
NMLCCIYSSN MELLQGPFYL NRRQAVLGSS YLYIVITLYI QVLQQYRCLE VINSVNEKIL
QDIENHSMTL LEDAFKELTS ALEGRFEESY KIRISRCKAS GNFLNRSSRD HFISIVSGLN
LVYGFLMKDN LLANSQQQNK QLQMLRFGML AGLSRLVCPN ELGKKFSTSC RRIEDNIARL
YLQTSIYCSV RDVEDNIKHW KQRDLCPEVT IPCFTVYGTF VNSDRQLIFD IYNVHIYNKE
MDNFDESCIS VLEETAERHM LWELDLMNSL CSDEKRDART ARLLLGCPNV RKAANKEGKK
LLKLNSDAST DTQSVASEVS DRRSYSSSKS RIRSIFGRYN SQKKPFELRS GLEVFNDPFN
DYQQAITDIC QFSEYTPNKE SILKDCLQII RKNPSHTMGS FELIQAVSEF GMSKFPPENI
DKARRDPKNW VSISEVTETT SIVASPKTHM MLKDCFKIIL GTENKKIVKM LRGKLKKLGA
ISTNIEIGKR DCLDLLSTVD GLTDQQKENI VNGIFEPSKL SFYHWKELVK KNIDEVLLTE
DGNLIFCWLK TISSSVKGSL KKRLKFMNIH SPELMPENCL FSSEEFNELI KLKKLLLNEQ
QDEQELKQDL LISSWIKCIT ACKDFASIND KVQKFIYHLS EELYNIRLQH LELSKLKQEH
PSVSFTKEEV LIKRLEKNFL KQHNLEIMET VNLIFFAALS APWCLHYKAL ESYLVRHPEI
LDCGSKEDCR LTLLDLSVSK LLVCLYRRND EELTNSSSLK LGFLVKYAVT LFTSNGEPFS
LSLNDGGLDL DLHKTTDEKL LHQTKIVFAK IGLSGNGYDF IWTTQMIANS NFNVCKRLTG
RSTGERLPRS VRSKVIYEMV KLVGETGMAI LQQLAFAQAL NYEHRFYAVL APKAQLGGAR
DLLVQETGTK VMHATTEMFS RNLLKTTSDD GLTNPHLKET ILNVGLDCLT NMRNLDGKPI
SEGSNLVNFY KVICISGDNT KWGPIHCCSF FSGMMQQVLK NVPDWCSFYK LTFIKNLCRQ
VEIPAGSIKK ILNVLRYKLC SKGGVEQHSE EDLRKLLVDN LDSWDGNDTV KFLVTTYISK
GLMALNSYNH MGQGIHHATS SVLTSLAAVL FEELAIFYLK RSLPQTTVHV EHAGSSDDYA
KCIVVTGILS RELYSQYDET FWKHACRLKN FTAAVQRCCQ MKDSAKTLVS DCFLEFYSEF
MMGYRVTPAV IKFMFTGLIN SSLTSPQSLM QACQVSSQQA MYNSVPLVTN TTFTLLRQQI
FFNHVEDFIR RYGILTLGTL SPFGRLFVPT YSGLVSSAVA LEDAEVIARA AQTLHMNSVS
IQSSSLTSLD SLGRSRTSST IEDSSSVSDT TVASHDSGSS SSSFSFELNR PLSETELQFI
KALNSLKSTQ ACEIIQNRIT GLYCNSNEGP LDRHNVIYSS RMADSCDWLR DGKRRGNLEL
ANRIQSVLCV LIAGYYRSFG GEGTEKQVKA SLNRDDNKII EDPMIQLIPE KLRRELERLG
VSRMEVDELM PSISPDDTLA QLVAKKLISL NVSTEEYSAE VSRLKQTLTA RNVLHGLAGG
IKELSLPIYT IFMKSYFFKD NVFLSLTDRW STKHSTNYRD SCGKQLTGRI ITKYTHWLDT
FLSCSVSINR HTTVKEPSLF NPNIRCVNLI TFEDGLRELS VIQSHLKVFE NEFTNLNLQF
SDPNRQKLRI VESRPAESEL EANRAVIVKT KLFSATEQVR LSNNPAVVMG YLLDESAISE
VKPTKVDFSN LLKDRFKIMQ FFPSVFTLIK MLTDESSDSE KTGLSPDLQQ VARYSNHLTL
LSRMIQQAKP TVTVFYMLKG NLMNTEPTVA ELVSYGIKEG RFYRLSDTGI DASTYSVKYW
KILHCISAIG CLPLSQADKS SLLMSFLNWR VNMDIRASDC PLSSHEASIL SEFDGQVIAN
ILASELSSVK RDSEREGLTD LLDYLNSPTE LLKKKPYLGT TCKFNTWGDS NRSGKFTYSS
RSGESIGIFI AGKLHIHLSS ESIALLCETE RQVLSWMSKR RTEIITKEQH QLFLSLLPQS
HECLQKHKDG SALSVIPDGS NPRLLKFVPL KKGLAVVKIK KQILTVKKQV VFDAESEPRL
QWGHGCLSIV YDETDTQTTY HENLLKVKQL VDCSTDRKKL LPQSVFSDSK VVLSRIKFKT
ELLLNSLTLL HCFLKHAPSD AIMEVESKSS LLHKYLKSGG VRQRNTEVLF REKLNKVVIK
DNLEQGVEEE IEFCNNLTKN VSENPLPLSC WSEVQNYIED IGFNNVLVNI DRNTVKSELL
WKFTLDTNVS TTSTIKDVRT LVSYVSTETI PKFLLAFLLY EEVLMNLISQ CKAVKELINS
TGLSDLELES LLTLCAFYFQ NECSKRDGPR CSFAALLSLV HEDWQKVGKN ILVRANNELG
DVSLKVNIVL VPLKDMSKSK PERVVIARRS LNHALSLMFL DEMSLPELKS LSVNCRMGNF
EGQECFEFTI LKDNSTRLDY NKLVDHCVDM EKKRDAVRAV EDLVLMLTGR AVKPSTVTPA
AHKDEQCQEQ ISLDDLMASD TVTDLPDREA EALKTGNLGF NWDSD
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