ID J7FP13_NOTVI Unreviewed; 234 AA.
AC J7FP13;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=WNT1 inducible signaling pathway protein 1 {ECO:0000313|EMBL:AFP43736.1};
DE Flags: Fragment;
GN Name=wisp1 {ECO:0000313|EMBL:AFP43736.1};
OS Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae;
OC Notophthalmus.
OX NCBI_TaxID=8316 {ECO:0000313|EMBL:AFP43736.1};
RN [1] {ECO:0000313|EMBL:AFP43736.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22891955; DOI=10.1021/pr300521p;
RA Looso M., Michel C.S., Konzer A., Bruckskotten M., Borchardt T.,
RA Krueger M., Braun T.;
RT "Spiked-in pulsed in vivo labeling identifies a new member of the CCN
RT family in regenerating newt hearts.";
RL J. Proteome Res. 11:4693-4704(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JX094348; AFP43736.1; -; mRNA.
DR AlphaFoldDB; J7FP13; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR043973; TSP1_CCN.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11348:SF4; CCN FAMILY MEMBER 4; 1.
DR PANTHER; PTHR11348; CONNECTIVE TISSUE GROWTH FACTOR-RELATED; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR Pfam; PF19035; TSP1_CCN; 1.
DR Pfam; PF00093; VWC; 1.
DR SMART; SM00041; CT; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 14..79
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 165..234
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFP43736.1"
FT NON_TER 234
FT /evidence="ECO:0000313|EMBL:AFP43736.1"
SQ SEQUENCE 234 AA; 26474 MW; E8FBC5D9BAA2FD5B CRC64;
PRYAIGVCAQ MTGVGCLLNG IRYVNGQTFQ PNCKYNCTCL DGAIGCIPVC TNSRPPLVWC
QNPKLIKMAG QCCEQWICDD PRRIRKTLPR HVASSAYVED NESWHKNCII QTTSWSPCSK
TCGMGISTRI SNANDKCELR RERRLCNMRP CEVDITKHIR PGKKCLAVYR GDDPMNFTIS
GCRSKNAYRP KYCGVCVDER CCTPYKSKTI EVKFECPDGS SFSWNVMWIN ACFC
//
