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Database: UniProt
Entry: J7GSU1_9SAUR
LinkDB: J7GSU1_9SAUR
Original site: J7GSU1_9SAUR 
ID   J7GSU1_9SAUR            Unreviewed;       218 AA.
AC   J7GSU1;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE            Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE   Flags: Fragment;
GN   Name=NT3 {ECO:0000313|EMBL:AFP73646.1};
OS   Varanus bushi.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus.
OX   NCBI_TaxID=555248 {ECO:0000313|EMBL:AFP73646.1};
RN   [1] {ECO:0000313|EMBL:AFP73646.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=22809723; DOI=10.1098/rsbl.2012.0460;
RA   Vidal N., Marin J., Sassi J., Battistuzzi F.U., Donnellan S., Fitch A.J.,
RA   Fry B.G., Vonk F.J., Rodriguez de la Vega R.C., Couloux A., Hedges S.B.;
RT   "Molecular evidence for an Asian origin of monitor lizards followed by
RT   Tertiary dispersals to Africa and Australasia.";
RL   Biol. Lett. 0:853-855(2012).
CC   -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC       sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC       ECO:0000256|RuleBase:RU365037}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU365037}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
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DR   EMBL; JQ844908; AFP73646.1; -; Genomic_DNA.
DR   AlphaFoldDB; J7GSU1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   InterPro; IPR015578; Neurotrophin-3.
DR   InterPro; IPR045815; NTF3_N.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR   Pfam; PF00243; NGF; 1.
DR   Pfam; PF19338; NTF3_N; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01914; NEUROTROPHN3.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW   Growth factor {ECO:0000256|RuleBase:RU365037};
KW   Secreted {ECO:0000256|RuleBase:RU365037};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          136..218
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFP73646.1"
FT   NON_TER         218
FT                   /evidence="ECO:0000313|EMBL:AFP73646.1"
SQ   SEQUENCE   218 AA;  24933 MW;  D709D64D0FD71144 CRC64;
     FAYLHGIQST NMDQGNLPED SINSLIIKLI QADILKNKES KQMLDIKDSV QATMKKTESI
     EPDIDDNENV KLDFPPVLEM DTELLRQQRR YSSPRVLFSD NTPLEPPPLY LMEDYIGSSV
     VVNRTTRRKR FAESKSHRGE YSVCDSESRW VTDKSSAIDI RGHQVTVLGE IKMGPSPVKQ
     YFYETRCKQA KPAKSGCRGI DDKHWNSQCK TSQTFVRA
//
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