ID   J7GY01_9CHAR            Unreviewed;       144 AA.
AC   J7GY01;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
GN   Name=BDNF {ECO:0000313|EMBL:AFP87580.1};
OS   Haematopus leucopodus.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Charadriiformes; Haematopodidae;
OC   Haematopus.
OX   NCBI_TaxID=555262 {ECO:0000313|EMBL:AFP87580.1};
RN   [1] {ECO:0000313|EMBL:AFP87580.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AJB3392 {ECO:0000313|EMBL:AFP87580.1}, and AJB3393
RC   {ECO:0000313|EMBL:AFP87581.1};
RX   PubMed=22842291; DOI=10.1016/j.ympev.2012.07.018;
RA   Baker A.J., Yatsenko Y., Tavares E.S.;
RT   "Eight independent nuclear genes support monophyly of the plovers: The role
RT   of mutational variance in gene trees.";
RL   Mol. Phylogenet. Evol. 65:631-641(2012).
CC   -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC       located either in the central nervous system or directly connected to
CC       it. {ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR   EMBL; JX470611; AFP87580.1; -; Genomic_DNA.
DR   EMBL; JX470612; AFP87581.1; -; Genomic_DNA.
DR   AlphaFoldDB; J7GY01; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Growth factor {ECO:0000256|RuleBase:RU364086}.
FT   DOMAIN          89..144
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFP87580.1"
FT   NON_TER         144
FT                   /evidence="ECO:0000313|EMBL:AFP87580.1"
SQ   SEQUENCE   144 AA;  16095 MW;  34C72149FA7B2277 CRC64;
     ESINGPNAGS RGLTSLADTF EHVIEELLDE DQDIQPSEEN KDADLYTSRV MLSSQVPLEP
     PLLFLLEEYK NYLDAANMSM RVRRHSDPAR RGELSVCDST SEWVTAAEKK TAVDMSGATV
     TVLEKVPVPK GQLKQYFYET KCNP
//