ID J7H3X0_9CHAR Unreviewed; 155 AA.
AC J7H3X0;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Bone morphogenetic protein 2 {ECO:0000313|EMBL:AFP87601.1};
DE Flags: Fragment;
OS Haematopus leucopodus.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Charadriiformes; Haematopodidae;
OC Haematopus.
OX NCBI_TaxID=555262 {ECO:0000313|EMBL:AFP87601.1};
RN [1] {ECO:0000313|EMBL:AFP87601.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AJB3392 {ECO:0000313|EMBL:AFP87601.1}, and AJB3393
RC {ECO:0000313|EMBL:AFP87602.1};
RX PubMed=22842291; DOI=10.1016/j.ympev.2012.07.018;
RA Baker A.J., Yatsenko Y., Tavares E.S.;
RT "Eight independent nuclear genes support monophyly of the plovers: The role
RT of mutational variance in gene trees.";
RL Mol. Phylogenet. Evol. 65:631-641(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; JX470632; AFP87601.1; -; Genomic_DNA.
DR EMBL; JX470633; AFP87602.1; -; Genomic_DNA.
DR AlphaFoldDB; J7H3X0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF143; BONE MORPHOGENETIC PROTEIN 2; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Chondrogenesis {ECO:0000256|ARBA:ARBA00023188};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 95..155
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 87..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..108
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFP87601.1"
FT NON_TER 155
FT /evidence="ECO:0000313|EMBL:AFP87601.1"
SQ SEQUENCE 155 AA; 18087 MW; F6C90781B221CC32 CRC64;
KDPVTRLLDT RLVHHNASKW ESFDVTPAVL RWIAHGQPNH GFVVEVVHLD KENSASKRHV
RISRSLHQDE DSWSQLRPLL VTFGHDGKGH PLHKREKRQA KHKQRKRHKY SCKRHPLYVD
FNDVGWNDWI VAPPGYSAFY CHGECPFPLA DHLNS
//
