ID J7H414_PLUSQ Unreviewed; 189 AA.
AC J7H414;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE Flags: Fragment;
OS Pluvialis squatarola (Grey plover) (Charadrius squatarola).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Charadriiformes; Charadriidae; Pluvialis.
OX NCBI_TaxID=171273 {ECO:0000313|EMBL:AFP87651.1};
RN [1] {ECO:0000313|EMBL:AFP87651.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AJB6138a {ECO:0000313|EMBL:AFP87650.1}, and AJB6142
RC {ECO:0000313|EMBL:AFP87651.1};
RX PubMed=22842291; DOI=10.1016/j.ympev.2012.07.018;
RA Baker A.J., Yatsenko Y., Tavares E.S.;
RT "Eight independent nuclear genes support monophyly of the plovers: The role
RT of mutational variance in gene trees.";
RL Mol. Phylogenet. Evol. 65:631-641(2012).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
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DR EMBL; JX470681; AFP87650.1; -; Genomic_DNA.
DR EMBL; JX470682; AFP87651.1; -; Genomic_DNA.
DR AlphaFoldDB; J7H414; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW Growth factor {ECO:0000256|RuleBase:RU365037};
KW Secreted {ECO:0000256|RuleBase:RU365037};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 121..189
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFP87651.1"
FT NON_TER 189
FT /evidence="ECO:0000313|EMBL:AFP87651.1"
SQ SEQUENCE 189 AA; 21701 MW; 970DFEABAEB7CF69 CRC64;
RSLPEDSINS LIIKLIQADI LKNKLSKQMV DIKENYQNTV QKADTQQDMD GDENVKSDFQ
PVISMDTDLL RQQRRYNSPR VLLSDNTPLE PPPLYLMEDY VGNSVVVNRT SRRKRYAEHK
SHRGEYSVCD SESLWVTDKS SAIDIRGHQV TVLGEIKTGN SPVKQYFYET RCKEAKPVKN
GCRGIDDKH
//
