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Database: UniProt
Entry: J7IRN4_DESMD
LinkDB: J7IRN4_DESMD
Original site: J7IRN4_DESMD 
ID   J7IRN4_DESMD            Unreviewed;       327 AA.
AC   J7IRN4;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   25-OCT-2017, entry version 30.
DE   SubName: Full=ATPase involved in DNA replication initiation {ECO:0000313|EMBL:AFQ44537.1};
GN   OrderedLocusNames=Desmer_2623 {ECO:0000313|EMBL:AFQ44537.1};
OS   Desulfosporosinus meridiei (strain ATCC BAA-275 / DSM 13257 / NCIMB
OS   13706 / S10).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Peptococcaceae;
OC   Desulfosporosinus.
OX   NCBI_TaxID=768704 {ECO:0000313|EMBL:AFQ44537.1, ECO:0000313|Proteomes:UP000005262};
RN   [1] {ECO:0000313|EMBL:AFQ44537.1, ECO:0000313|Proteomes:UP000005262}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-275 / DSM 13257 / NCIMB 13706 / S10
RC   {ECO:0000313|Proteomes:UP000005262};
RX   PubMed=23105050; DOI=10.1128/JB.01392-12;
RA   Pester M., Brambilla E., Alazard D., Rattei T., Weinmaier T., Han J.,
RA   Lucas S., Lapidus A., Cheng J.F., Goodwin L., Pitluck S., Peters L.,
RA   Ovchinnikova G., Teshima H., Detter J.C., Han C.S., Tapia R.,
RA   Land M.L., Hauser L., Kyrpides N.C., Ivanova N.N., Pagani I.,
RA   Huntmann M., Wei C.L., Davenport K.W., Daligault H., Chain P.S.,
RA   Chen A., Mavromatis K., Markowitz V., Szeto E., Mikhailova N.,
RA   Pati A., Wagner M., Woyke T., Ollivier B., Klenk H.P., Spring S.,
RA   Loy A.;
RT   "Complete genome sequences of Desulfosporosinus orientis DSM765T,
RT   Desulfosporosinus youngiae DSM17734T, Desulfosporosinus meridiei
RT   DSM13257T, and Desulfosporosinus acidiphilus DSM22704T.";
RL   J. Bacteriol. 194:6300-6301(2012).
RN   [2] {ECO:0000313|Proteomes:UP000005262}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-275 / DSM 13257 / NCIMB 13706 / S10
RC   {ECO:0000313|Proteomes:UP000005262};
RA   Huntemann M., Wei C.-L., Han J., Detter J.C., Han C., Davenport K.,
RA   Daligault H., Erkkila T., Gu W., Munk A.C.C., Teshima H., Xu Y.,
RA   Chain P., Tapia R., Chen A., Krypides N., Mavromatis K., Markowitz V.,
RA   Szeto E., Ivanova N., Mikhailova N., Ovchinnikova G., Pagani I.,
RA   Pati A., Goodwin L., Peters L., Pitluck S., Woyke T., Pester M.,
RA   Spring S., Ollivier B., Rattei T., Klenk H.-P., Wagner M., Loy A.;
RT   "Finished genome of Desulfosporosinus meridiei DSM 13257.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|SAAS:SAAS00747914}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP003629; AFQ44537.1; -; Genomic_DNA.
DR   RefSeq; WP_014903450.1; NC_018515.1.
DR   EnsemblBacteria; AFQ44537; AFQ44537; Desmer_2623.
DR   KEGG; dmi:Desmer_2623; -.
DR   KO; K02313; -.
DR   OMA; HTYEALF; -.
DR   OrthoDB; POG091H02FF; -.
DR   BioCyc; DMER768704:GLCK-2506-MONOMER; -.
DR   Proteomes; UP000005262; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005262};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005262}.
FT   DOMAIN       24    155       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      231    299       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   327 AA;  37937 MW;  A53446078A4ABAA8 CRC64;
     MNWFVRDFNI RACRLAKKFQ FENAPNVTLI YGPRGVGKSA LLQYLYKKNQ SENGLVITDA
     LAFARQYAYA AQERNLNQFR ERYRSTRLLL IDDLQCLAGK AKTIEELHYT YEYINNNGGK
     LVITCEADRL DLGFLGERLA SRLLSGVAIP IERPQEFELE AFLEEYVHQK RLFVAKSVLC
     MISKRIDNLA DAVKTIGDYI KFAELHEDEL SLACFQAYWY EKERKMLKAP DPINIIRNVA
     QTMGVSVEDL QSASRKKNVN EVREMAIYAI RSLCHISFPA IASYFNRNHN SIILSYQKMQ
     DKLVKDKELI RIYQSVLNCF DHEETIE
//
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