ID J7L512_NOCAA Unreviewed; 715 AA.
AC J7L512;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=MMPL family protein {ECO:0000313|EMBL:AFR08733.1};
GN OrderedLocusNames=B005_0699 {ECO:0000313|EMBL:AFR08733.1};
OS Nocardiopsis alba (strain ATCC BAA-2165 / BE74).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Nocardiopsis.
OX NCBI_TaxID=1205910 {ECO:0000313|EMBL:AFR08733.1, ECO:0000313|Proteomes:UP000003779};
RN [1] {ECO:0000313|EMBL:AFR08733.1, ECO:0000313|Proteomes:UP000003779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2165 / BE74 {ECO:0000313|Proteomes:UP000003779};
RX PubMed=23105086; DOI=10.1128/JB.01522-12;
RA Qiao J., Chen L., Li Y., Wang J., Zhang W., Chen S.;
RT "Whole-Genome Sequence of Nocardiopsis alba Strain ATCC BAA-2165,
RT Associated with Honeybees.";
RL J. Bacteriol. 194:6358-6359(2012).
RN [2] {ECO:0000313|Proteomes:UP000003779}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-2165 / BE74 {ECO:0000313|Proteomes:UP000003779};
RA Qiao J., Chen L., Li Y., Wang J., Zhang W., Chen S.;
RT "Whole-genome sequence of Nocardiopsis alba strain ATCC BAA-2165 associated
RT with honeybees.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP003788; AFR08733.1; -; Genomic_DNA.
DR AlphaFoldDB; J7L512; -.
DR STRING; 1205910.B005_0699; -.
DR KEGG; nal:B005_0699; -.
DR PATRIC; fig|1205910.3.peg.658; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_4_1_11; -.
DR Proteomes; UP000003779; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003779};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 535..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 634..657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 568..692
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 715 AA; 74199 MW; 3E18621D1373B30E CRC64;
MSTPSQNPPR RSRWWAGAAL LVTIVWILGA GPLGAFLGRL GEVQTNDPAA FLPDGAESTE
ADRIAQDFDR ADGVPAFIVL SGDDAITGDL LAEAETLAER IGEQPWTTGP VIGPLPGTED
PSIARIIVSI DDRHDTGDSV AELRALLADE PVDGLRAEVT GPAGYAADLV AAFGGIDSTL
LVVAVVAVLV ILIAVYRSPL LPILVIVASL LALGLSGALV YAAADSGLIS LNGQSQGILF
ILVVGACTDY ALLLVARYRE ELAARESVTD AVLAAVRGVT GPVLASGGTV ILGLLCLLAA
DLNSTSSLGP VVAIGVVAAM LAAMTFLPAA LALCGRAAFW PVSPHRLGRV EEQSTDRILE
RHRLWGGIAR LVGRRPRLIW LSTTALLLAA AVFAPLFTAE GTGQADVFRT EVEAVDGQET
LERGFGPDSG AAPALVVTDA DRVDEIVAAA EDTPGVEAAI PVSEPGPPGA EGAVLVEDGR
SLVEVDLAAV SETTAAVDTV RDLRESVHAV AGADALVGGV DATDLDTRET ARRDFAVVVP
LVLVVVFLVL IPLLRSLVAP LLLMAVNVLS FATALGVGTL VFDHVLDLPG ADPVVPLFAF
VFLVALGIDY SIFLMSRARE ETLVHGHREG VLRALTVTGG VITSAGVVLA ATFAALAVIP
LLFLLQLAFL VAFGVLVDAL LVRTLLIPAL ALDVGPRLWW PGRAGEQDPP SHQRV
//
