ID J7LJW1_HASV2 Unreviewed; 244 AA.
AC J7LJW1;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=RNA-dependent RNA polymerase {ECO:0000313|EMBL:AFR23485.1};
DE Flags: Fragment;
GN Name=ORF1b {ECO:0000313|EMBL:AFR23485.1};
OS Human astrovirus-2 (HAstV-2).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC Stellavirales; Astroviridae; Mamastrovirus; Mamastrovirus 1.
OX NCBI_TaxID=12701 {ECO:0000313|EMBL:AFR23485.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AFR23485.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ITA/2002/PA65R/type2c {ECO:0000313|EMBL:AFR23485.1};
RX PubMed=22933603; DOI=10.1128/JCM.02102-12;
RA De Grazia S., Medici M.C., Pinto P., Moschidou P., Tummolo F.,
RA Calderaro A., Bonura F., Banyai K., Giammanco G.M., Martella V.;
RT "Genetic heterogeneity and recombination in human type 2 astroviruses.";
RL J. Clin. Microbiol. 50:3760-3764(2012).
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000256|ARBA:ARBA00004301};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004301}.
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DR EMBL; JX087963; AFR23485.1; -; Genomic_RNA.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd23172; ps-ssRNAv_Astroviridae_RdRp; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR Pfam; PF00680; RdRP_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW ECO:0000313|EMBL:AFR23485.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 1..171
FT /note="RNA-directed RNA polymerase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00680"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFR23485.1"
SQ SEQUENCE 244 AA; 28225 MW; 904A264C0E3ECD05 CRC64;
GTIPPALFRH IKEIRWNFIN KDQREKYRHV HEWYVDNLLN RHVLLPSGEV TVQTRGNPSG
QFSTTMDNNM VNFWLQAFEF AYFNGPNKDL WKTYDTVVYG DDRLSTTPSV PDNYEERVIA
MYRDIFGMWV KPGKVICRES IVGLSFCGFT VNSDLEPVPT SPEKLMASLL KPYKVLPDLE
SLHGKLLCYQ LLAAFMAEDH PFKVYVEHCL SRTAKQLRES GLPARLTEEQ LHRIWRGGPK
KCDG
//
