ID J7M6V2_STRP1 Unreviewed; 429 AA.
AC J7M6V2;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 2.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Zinc protease {ECO:0000313|EMBL:BAM31208.2};
DE EC=3.4.-.- {ECO:0000313|EMBL:BAM31208.2};
GN ORFNames=M1GAS476_1899 {ECO:0000313|EMBL:BAM31208.2};
OS Streptococcus pyogenes M1 476.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1207470 {ECO:0000313|EMBL:BAM31208.2, ECO:0000313|Proteomes:UP000005248};
RN [1] {ECO:0000313|EMBL:BAM31208.2, ECO:0000313|Proteomes:UP000005248}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=476 {ECO:0000313|Proteomes:UP000005248};
RX PubMed=22965090; DOI=10.1128/JB.01265-12;
RA Miyoshi-Akiyama T., Watanabe S., Kirikae T.;
RT "Complete Genome Sequence of Streptococcus pyogenes M1 476, Isolated from a
RT Patient with Streptococcal Toxic Shock Syndrome.";
RL J. Bacteriol. 194:5466-5466(2012).
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DR EMBL; AP012491; BAM31208.2; -; Genomic_DNA.
DR RefSeq; WP_010922796.1; NC_020540.2.
DR AlphaFoldDB; J7M6V2; -.
DR KEGG; spym:M1GAS476_1899; -.
DR HOGENOM; CLU_052317_0_0_9; -.
DR Proteomes; UP000005248; Chromosome 1.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR PANTHER; PTHR11851:SF134; ZINC-DEPENDENT PROTEASE; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:BAM31208.2};
KW Protease {ECO:0000313|EMBL:BAM31208.2}.
FT DOMAIN 62..176
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 188..362
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 429 AA; 49186 MW; 2FA63CCA56D1257D CRC64;
MTKLVKINYP NIDEDLYYVK LENGLTVYFI KKIGFLEKTA MLTVGFGSLD NKLTVDDESR
DAPAGIAHFL EHKLFEDESG GDISLKFTQL GAETNAFTTF NQTSFFFSTA SKFQENLELL
QYFVLSANIT DESVSREKKI IGQEIDMYQD DADYRAYSGI LQNLFPKTSL ANDIAGSKAS
IQKITKILLE THHTYFYQPT NMSLFIVGDI DIDETFLAIQ RFQTTLSYPD RKRVTVDPLH
YYPVIKSSSV DMDVTTAKLV VGFRGYLTLT QHSLLTYRIA LKLFLSMLIG WTSKIYHTLY
EDGKIDDSFD VDVEIHHNFQ FVLISLDTPE PIAMSNYIRQ KLATIKISKE FTNEHLNLLK
KEMYGDFIQS LDSIEHLTHQ FSLYLSDSDK ETYFDIPKII ERLTLKDVVT IGKAFFEKAD
ASDFTVFPK
//
