ID J7M8P2_9NIDO Unreviewed; 419 AA.
AC J7M8P2;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=sialate O-acetylesterase {ECO:0000256|ARBA:ARBA00013141};
DE EC=3.1.1.53 {ECO:0000256|ARBA:ARBA00013141};
GN Name=HE {ECO:0000313|EMBL:BAM36712.1};
OS Bovine torovirus.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Tornidovirineae; Tobaniviridae; Torovirinae; Torovirus;
OC Renitovirus.
OX NCBI_TaxID=74501 {ECO:0000313|EMBL:BAM36712.1};
RN [1] {ECO:0000313|EMBL:BAM36712.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Niigata1 {ECO:0000313|EMBL:BAM36712.1};
RX PubMed=22167249; DOI=10.1007/s00705-011-1183-9;
RA Aita T., Kuwabara M., Murayama K., Sasagawa Y., Yabe S., Higuchi R.,
RA Tamura T., Miyazaki A., Tsunemitsu H.;
RT "Characterization of epidemic diarrhea outbreaks associated with bovine
RT torovirus in adult cows.";
RL Arch. Virol. 157:423-431(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-
CC acetylneuraminate; Xref=Rhea:RHEA:25564, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29006, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:35418; EC=3.1.1.53;
CC Evidence={ECO:0000256|ARBA:ARBA00000954};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-
CC acetylneuraminate; Xref=Rhea:RHEA:22600, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:28999, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:35418; EC=3.1.1.53;
CC Evidence={ECO:0000256|ARBA:ARBA00001221};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Host cell membrane {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I
CC membrane protein {ECO:0000256|ARBA:ARBA00004402}.
CC -!- SIMILARITY: Belongs to the influenza type C/coronaviruses
CC hemagglutinin-esterase family. {ECO:0000256|ARBA:ARBA00010920}.
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DR EMBL; AB661456; BAM36712.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR GO; GO:0106331; F:sialate 4-O-acetylesterase activity; IEA:UniProtKB-EC.
DR GO; GO:0106330; F:sialate 9-O-acetylesterase activity; IEA:UniProtKB-EC.
DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
DR InterPro; IPR008980; Capsid_hemagglutn.
DR InterPro; IPR007142; Hemagglutn-estrase_core.
DR InterPro; IPR003860; Hemagglutn-estrase_hemagglutn.
DR Pfam; PF03996; Hema_esterase; 1.
DR Pfam; PF02710; Hema_HEFG; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR SUPFAM; SSF49818; Viral protein domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Virion {ECO:0000256|ARBA:ARBA00022844}.
FT TRANSMEM 392..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..377
FT /note="Haemagglutinin-esterase glycoprotein core"
FT /evidence="ECO:0000259|Pfam:PF03996"
FT DOMAIN 122..261
FT /note="Haemagglutinin-esterase glycoprotein haemagglutinin"
FT /evidence="ECO:0000259|Pfam:PF02710"
SQ SEQUENCE 419 AA; 46720 MW; 558A55C16B7DD65E CRC64;
MLSLIFFFPS FAFSATPVTP YYGPGHITSD WCGFGDSRSD CTNPYSPMSL DIPQQLCSKF
SSKSSSSMFL SLHWNTSSSF VSYDYFNCGV EKVFYEGVNF SPRRQYSCWD EGVDGWTEFK
TRFYTKLYQM AATSRCIKLI QLQPPTRLPT LTAAVCRTGK QLPDNPKFGL LADTNPTSVQ
FVLPGSSGTT ICTKHLVPFC YLNHGCFTAG GSCLPFGVSY VSNSFYYGYY DATPQIGSIE
SHDYVCDYLF MEPGTYNAST VGKFLVYPTK SYCMDTMNIT VPVQAVQSIW SEQYASDDAI
GQACKAPYCI FYNKTTSYTV TNGSDANHGD DEVRMMMQGL LRNSSCISPQ GSTPLALYSS
QMIYSPNYGS CPQYYKLFET SSDENVDVTS SAYFVATWVL LVLVIILIFI LISFCLSSY
//