GenomeNet

Database: UniProt
Entry: J7M8P2_9NIDO
LinkDB: J7M8P2_9NIDO
Original site: J7M8P2_9NIDO 
ID   J7M8P2_9NIDO            Unreviewed;       419 AA.
AC   J7M8P2;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=sialate O-acetylesterase {ECO:0000256|ARBA:ARBA00013141};
DE            EC=3.1.1.53 {ECO:0000256|ARBA:ARBA00013141};
GN   Name=HE {ECO:0000313|EMBL:BAM36712.1};
OS   Bovine torovirus.
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Tornidovirineae; Tobaniviridae; Torovirinae; Torovirus;
OC   Renitovirus.
OX   NCBI_TaxID=74501 {ECO:0000313|EMBL:BAM36712.1};
RN   [1] {ECO:0000313|EMBL:BAM36712.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Niigata1 {ECO:0000313|EMBL:BAM36712.1};
RX   PubMed=22167249; DOI=10.1007/s00705-011-1183-9;
RA   Aita T., Kuwabara M., Murayama K., Sasagawa Y., Yabe S., Higuchi R.,
RA   Tamura T., Miyazaki A., Tsunemitsu H.;
RT   "Characterization of epidemic diarrhea outbreaks associated with bovine
RT   torovirus in adult cows.";
RL   Arch. Virol. 157:423-431(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-
CC         acetylneuraminate; Xref=Rhea:RHEA:25564, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29006, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:35418; EC=3.1.1.53;
CC         Evidence={ECO:0000256|ARBA:ARBA00000954};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-
CC         acetylneuraminate; Xref=Rhea:RHEA:22600, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:28999, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:35418; EC=3.1.1.53;
CC         Evidence={ECO:0000256|ARBA:ARBA00001221};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Host cell membrane {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I
CC       membrane protein {ECO:0000256|ARBA:ARBA00004402}.
CC   -!- SIMILARITY: Belongs to the influenza type C/coronaviruses
CC       hemagglutinin-esterase family. {ECO:0000256|ARBA:ARBA00010920}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB661456; BAM36712.1; -; Genomic_RNA.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR   GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR   GO; GO:0106331; F:sialate 4-O-acetylesterase activity; IEA:UniProtKB-EC.
DR   GO; GO:0106330; F:sialate 9-O-acetylesterase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
DR   InterPro; IPR008980; Capsid_hemagglutn.
DR   InterPro; IPR007142; Hemagglutn-estrase_core.
DR   InterPro; IPR003860; Hemagglutn-estrase_hemagglutn.
DR   Pfam; PF03996; Hema_esterase; 1.
DR   Pfam; PF02710; Hema_HEFG; 1.
DR   SUPFAM; SSF52266; SGNH hydrolase; 1.
DR   SUPFAM; SSF49818; Viral protein domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Virion {ECO:0000256|ARBA:ARBA00022844}.
FT   TRANSMEM        392..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          2..377
FT                   /note="Haemagglutinin-esterase glycoprotein core"
FT                   /evidence="ECO:0000259|Pfam:PF03996"
FT   DOMAIN          122..261
FT                   /note="Haemagglutinin-esterase glycoprotein haemagglutinin"
FT                   /evidence="ECO:0000259|Pfam:PF02710"
SQ   SEQUENCE   419 AA;  46720 MW;  558A55C16B7DD65E CRC64;
     MLSLIFFFPS FAFSATPVTP YYGPGHITSD WCGFGDSRSD CTNPYSPMSL DIPQQLCSKF
     SSKSSSSMFL SLHWNTSSSF VSYDYFNCGV EKVFYEGVNF SPRRQYSCWD EGVDGWTEFK
     TRFYTKLYQM AATSRCIKLI QLQPPTRLPT LTAAVCRTGK QLPDNPKFGL LADTNPTSVQ
     FVLPGSSGTT ICTKHLVPFC YLNHGCFTAG GSCLPFGVSY VSNSFYYGYY DATPQIGSIE
     SHDYVCDYLF MEPGTYNAST VGKFLVYPTK SYCMDTMNIT VPVQAVQSIW SEQYASDDAI
     GQACKAPYCI FYNKTTSYTV TNGSDANHGD DEVRMMMQGL LRNSSCISPQ GSTPLALYSS
     QMIYSPNYGS CPQYYKLFET SSDENVDVTS SAYFVATWVL LVLVIILIFI LISFCLSSY
//
DBGET integrated database retrieval system