ID J7QWA8_METSZ Unreviewed; 507 AA.
AC J7QWA8;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Transcriptional regulator, GntR family with aminotransferase domain {ECO:0000313|EMBL:CCJ08665.1};
GN OrderedLocusNames=BN69_3214 {ECO:0000313|EMBL:CCJ08665.1};
OS Methylocystis sp. (strain SC2).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylocystaceae; Methylocystis.
OX NCBI_TaxID=187303 {ECO:0000313|EMBL:CCJ08665.1, ECO:0000313|Proteomes:UP000005263};
RN [1] {ECO:0000313|EMBL:CCJ08665.1, ECO:0000313|Proteomes:UP000005263}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC2 {ECO:0000313|EMBL:CCJ08665.1,
RC ECO:0000313|Proteomes:UP000005263};
RX PubMed=23045511; DOI=10.1128/JB.01446-12;
RA Dam B., Dam S., Kube M., Reinhardt R., Liesack W.;
RT "Complete Genome Sequence of Methylocystis sp. Strain SC2, an Aerobic
RT Methanotroph with High-Affinity Methane Oxidation Potential.";
RL J. Bacteriol. 194:6008-6009(2012).
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; HE956757; CCJ08665.1; -; Genomic_DNA.
DR RefSeq; WP_014892691.1; NC_018485.1.
DR AlphaFoldDB; J7QWA8; -.
DR STRING; 187303.BN69_3214; -.
DR KEGG; msc:BN69_3214; -.
DR PATRIC; fig|187303.17.peg.3477; -.
DR eggNOG; COG1167; Bacteria.
DR HOGENOM; CLU_017584_0_1_5; -.
DR OrthoDB; 9808770at2; -.
DR Proteomes; UP000005263; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:CCJ08665.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:CCJ08665.1}.
FT DOMAIN 30..98
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 507 AA; 55542 MW; 7CF693AD4F883BA0 CRC64;
MTFTTTDRPA PIVKSGHVQL SITLAESDKN TLQNQIFDQI RSMILSGQLK CDDPMPTTRE
LSSQLGVSRN TAVLAYERLI AEGYIRTKPY VGTFVSPDLP DTAFLSADQR TPQTEEQGAA
IDVPAACGAL RTHRLADPER RRLAADFWVG RPDARSFPLK AWSHHIKNRL KAVGANLTSY
NDAAGLMELR RAIAKHLAPA RGVVADPEQI VIVGGCQDGF NLVGRLLVTP GSTAVVESPC
YQGAAFVLES LGATLHPVPV DQDGLDVSRL PKTRGAVAYV TPSHQYPIGV TMSLQRRLEL
LAWATQYDAY IMEDDYDSDF RFIGSPLTAL KGLDRNERVI YLGTFSKCMG PGLRLGYVVL
PRRLAEAGRR MKMLMNNGQS WLEQAAMADF MSSGEFGRHL RRIRQLYRDR RDALLGALRN
HFGACEIYGD QAGMHLVWKL PDGFPDAAEV EKRGVAAGVG VCSLATGSAL RFDDVNGGDR
LLMLGFVALT EKEIETGIAR LAQALKA
//
