ID J7R0G6_ECOLX Unreviewed; 796 AA.
AC J7R0G6; A0A2A2XGD7;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family {ECO:0000313|EMBL:AXO05859.1};
DE EC=1.1.-.- {ECO:0000313|EMBL:AXO05859.1};
DE EC=1.1.5.2 {ECO:0000313|EMBL:AUK02667.1};
DE SubName: Full=Pyrroloquinoline quinone-dependent dehydrogenase {ECO:0000313|EMBL:EFB1697024.1};
GN ORFNames=CR538_20885 {ECO:0000313|EMBL:AUK02667.1}, DS732_05530
GN {ECO:0000313|EMBL:AXO05859.1}, FJQ40_06250
GN {ECO:0000313|EMBL:EFB1697024.1};
OS Escherichia coli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:AXO05859.1, ECO:0000313|Proteomes:UP000256244};
RN [1] {ECO:0000313|EMBL:AUK02667.1, ECO:0000313|Proteomes:UP000234238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=14EC029 {ECO:0000313|EMBL:AUK02667.1,
RC ECO:0000313|Proteomes:UP000234238};
RA Li B., Wang X.;
RT "mcr-1 positive E.coli isolates in China.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AXO05859.1, ECO:0000313|Proteomes:UP000256244}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cq9 {ECO:0000313|EMBL:AXO05859.1}, and cq9
RC {ECO:0000313|Proteomes:UP000256244};
RA Bai L.;
RT "Complete genome sequencing and genomic characterization of five
RT Escherichia coli strains co-producing MCR-1 and ESBLs from different
RT origins in China.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EFB1697024.1, ECO:0000313|Proteomes:UP000533284}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PSU-1847 {ECO:0000313|EMBL:EFB1697024.1,
RC ECO:0000313|Proteomes:UP000533284};
RG GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyrroloquinoline quinone; Xref=ChEBI:CHEBI:58442;
CC Evidence={ECO:0000256|ARBA:ARBA00001931};
CC -!- SIMILARITY: Belongs to the bacterial PQQ dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00008156}.
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DR EMBL; CP024141; AUK02667.1; -; Genomic_DNA.
DR EMBL; CP031546; AXO05859.1; -; Genomic_DNA.
DR EMBL; AASDBN010000008; EFB1697024.1; -; Genomic_DNA.
DR RefSeq; WP_001324194.1; NZ_WVUT01000005.1.
DR Proteomes; UP000234238; Chromosome.
DR Proteomes; UP000256244; Chromosome.
DR Proteomes; UP000533284; Unassembled WGS sequence.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR GO; GO:0008876; F:quinoprotein glucose dehydrogenase activity; IEA:UniProtKB-EC.
DR CDD; cd10280; PQQ_mGDH; 1.
DR Gene3D; 2.140.10.10; Quinoprotein alcohol dehydrogenase-like superfamily; 1.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR017511; PQQ_mDH.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR001479; Quinoprotein_DH_CS.
DR NCBIfam; TIGR03074; PQQ_membr_DH; 1.
DR PANTHER; PTHR32303; QUINOPROTEIN ALCOHOL DEHYDROGENASE (CYTOCHROME C); 1.
DR PANTHER; PTHR32303:SF4; QUINOPROTEIN GLUCOSE DEHYDROGENASE; 1.
DR Pfam; PF01011; PQQ; 6.
DR SMART; SM00564; PQQ; 6.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS00363; BACTERIAL_PQQ_1; 1.
DR PROSITE; PS00364; BACTERIAL_PQQ_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AXO05859.1}; PQQ {ECO:0000256|ARBA:ARBA00022891};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 796 AA; 86717 MW; B5911ABA00F35744 CRC64;
MAINNTGSRR LLVTLTALFA ALCGLYLLIG GGWLVAIGGS WYYPIAGLVM LGVAWMLWLS
KRAALWLYAA LLLGTMIWGV WEVGFDFWAL TPRSDILVFF GIWLILPFVW RRLVIPASGA
VAALVVALLI SGGILTWAGF NDPQEINGTL SADATPAEAI SPVADQDWPA YGRNQEGQRF
SPLKQINADN VHKLKEAWVF RTGDVKQPND PGEITNEVTP IKVGDTLYLC TAHQRLFALD
AASGKEKWHY DPELKTNESF QHVTCRGVSY HEAKAETASP EVMADCPRRI ILPVNDGRLI
AINAENGKLC ETFANKGVLN LQSNMPDTKP GLYEPTSPPI ITDKTIVMAG SVTDNFSTRE
TSGVIRGFDV NTGELLWAFD PGAKNPNAIP SDEHTFTFNS PNSWAPAAYD AKLDLVYLPM
GVTTPDIWGG NRTPEQERYA SSILALNATT GKLAWSYQTV HHDLWDMDLP AQPTLADITV
NGQKVPVIYA PAKTGNIFVL DRRNGELVVP APEKPVPQGA AKGDYVTPTQ PFSELSFRPT
KDLSGADMWG ATMFDQLVCR VMFHQMRYEG IFTPPSEQGT LVFPGNLGMF EWGGISVDPN
REVAIANPMA LPFVSKLIPR GPGNPMEQPK DAKGTGTESG IQPQYGVPYG VTLNPFLSPF
GLPCKQPAWG YISALDLKTN EVVWKKRIGT PQDSMPFPMP VPVPFNMGMP MLGGPISTAG
NVLFIAATAD NYLRAYNMSN GEKLWQGRLP AGGQATPMTY EVNGKQYVVI SAGGHGSFGT
KMGDYIVAYA LPDDVK
//
