ID J7RUP0_KAZNA Unreviewed; 222 AA.
AC J7RUP0;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CCK68557.1};
GN Name=KNAG0B01100 {ECO:0000313|EMBL:CCK68557.1};
GN OrderedLocusNames=KNAG_0B01100 {ECO:0000313|EMBL:CCK68557.1};
OS Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / KCTC
OS 17520 / NBRC 10181 / NCYC 3082 / Yp74L-3) (Yeast) (Saccharomyces
OS naganishii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071383 {ECO:0000313|EMBL:CCK68557.1, ECO:0000313|Proteomes:UP000006310};
RN [1] {ECO:0000313|EMBL:CCK68557.1, ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN [2] {ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Genome sequence of Kazachstania naganishii.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the RNase PH family.
CC {ECO:0000256|ARBA:ARBA00006678}.
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DR EMBL; HE978315; CCK68557.1; -; Genomic_DNA.
DR AlphaFoldDB; J7RUP0; -.
DR STRING; 1071383.J7RUP0; -.
DR eggNOG; KOG1069; Eukaryota.
DR HOGENOM; CLU_063514_2_1_1; -.
DR OMA; CIINEQG; -.
DR OrthoDB; 2996330at2759; -.
DR Proteomes; UP000006310; Chromosome 2.
DR GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IEA:UniProt.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:UniProt.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProt.
DR GO; GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IEA:UniProt.
DR GO; GO:0016075; P:rRNA catabolic process; IEA:UniProt.
DR CDD; cd11372; RNase_PH_RRP46; 1.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR015847; ExoRNase_PH_dom2.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR PANTHER; PTHR11953; EXOSOME COMPLEX COMPONENT; 1.
DR PANTHER; PTHR11953:SF1; EXOSOME COMPLEX COMPONENT RRP46; 1.
DR Pfam; PF01138; RNase_PH; 1.
DR Pfam; PF03725; RNase_PH_C; 1.
DR SUPFAM; SSF55666; Ribonuclease PH domain 2-like; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000006310};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 2..123
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF01138"
FT DOMAIN 141..199
FT /note="Exoribonuclease phosphorolytic"
FT /evidence="ECO:0000259|Pfam:PF03725"
SQ SEQUENCE 222 AA; 24440 MW; 4758FCF1A89602B6 CRC64;
MGIQTGYLDQ VDGSAHYKTD TTALLCSVTG PIEPKPRQEL PTRMALEVIV RPALGVPLTR
EVEIQDKLNS ILGSIIVVHR YPRQLCQITF QILESGEDPH LFDSKELVAC VNAATLALID
AGIAMNSLAI GCVIAVLPES DGKHIIDPTD EQLRNAISVH SLVLQLVDGS KVVNNVLLLD
SYGDFTEKIL FEVLELGEKY ILNKAQDFRK LIQERIEASI LK
//
