ID J7RVV7_KAZNA Unreviewed; 1080 AA.
AC J7RVV7;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|RuleBase:RU365058};
GN Name=KNAG0B06610 {ECO:0000313|EMBL:CCK69087.1};
GN OrderedLocusNames=KNAG_0B06610 {ECO:0000313|EMBL:CCK69087.1};
OS Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / KCTC
OS 17520 / NBRC 10181 / NCYC 3082 / Yp74L-3) (Yeast) (Saccharomyces
OS naganishii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071383 {ECO:0000313|EMBL:CCK69087.1, ECO:0000313|Proteomes:UP000006310};
RN [1] {ECO:0000313|EMBL:CCK69087.1, ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN [2] {ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Genome sequence of Kazachstania naganishii.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBUNIT: ORC is composed of six subunits.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365058}.
CC -!- SIMILARITY: Belongs to the ORC1 family.
CC {ECO:0000256|RuleBase:RU365058}.
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DR EMBL; HE978315; CCK69087.1; -; Genomic_DNA.
DR AlphaFoldDB; J7RVV7; -.
DR STRING; 1071383.J7RVV7; -.
DR eggNOG; KOG1514; Eukaryota.
DR HOGENOM; CLU_012774_1_1_1; -.
DR OMA; YICEPTA; -.
DR OrthoDB; 2040079at2759; -.
DR Proteomes; UP000006310; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032993; C:protein-DNA complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04720; BAH_Orc1p_Yeast; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR Pfam; PF13401; AAA_22; 1.
DR Pfam; PF01426; BAH; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00439; BAH; 1.
DR SUPFAM; SSF82061; BAH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51038; BAH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU365058};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU365058};
KW DNA-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleus {ECO:0000256|RuleBase:RU365058};
KW Reference proteome {ECO:0000313|Proteomes:UP000006310}.
FT DOMAIN 48..188
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 201..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 350..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..493
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..583
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1080 AA; 121190 MW; E5AD75147D9F62D9 CRC64;
MATTNEALRG WQVLVTDEKG NVITGSRRRS RKGGSVENVY LQRISDGLSF GRGDSVVAHD
ALTGTYSVYL VHEIRLNTLN NVAEIWAFSY LRSFELKPVK YYRQFAPELL ETRPSMESLH
ERLFAEVNAS ELYLTAELSE IWLRDFIGIA NILSKADWDA RGDAIRPDHD FFVRYICEPT
AENFVRIDIY KEVKKIQMMD PKRSDEHLKK LSVPPAKPSG KSGSVPHRPR IREKAIEVGN
SEPFAKREGS DTMEQTVQTV QTVQTPMKLP ILQPRDKKKT SVPMATGIKG ANEGDEKQKR
EQEQEQRKEQ EREQEQKQEK EQEQEKEQEQ EEEQVDNIAA APSPPPATAP ASSSAAETGS
APTSVSASGS AAIPAPDSTP PKSSKSLFIS EPDTSEDLNN NNKSSSDVSD PEEFASANDR
PTEDEIQSSS GSDIDHGFVV PNDHSVSHEE SSPDNADQDE EQEVDEQVYS SRAKRKAAHR
REALRRKKSR QARKTVMAGS DSELSEISDY EGAPKEPTQE TAQESKPESP SVTTDDSLIV
RKLDELKARE IRLRLTQKYK KLKKDYDVKG SSSASEDDEG SRSGSDGVMS SENSSIDVAG
LESKLRPADL GEKGTTIFSR LKGNGNLNDD LSIVETIESY VSLPARSKEF ARLYLELFDS
LRKKEPKAAF ISGKTNTGKS TIIQRVVEEL AKSSRCKELR IFDLVNVNRS LLDSGKQDVY
SSIWKQMTGE KLTGHVAQMA MKRYFTKLGE NTKRQTVIVV DDADLLANKW TNLLNDLFEW
SSCEISKLIF VVISTNPNLL RDNLNSHYLD SLTYLDIPFD DYSYEQLYNF SVFRMRSLLT
SEFTLVKSTD GSQWQFAPAD SIPAEFQVVR TVRLEMSESF IQEASEHFCQ LRLDIVGILR
LLRDAVKYCQ SNYLETKCNT VGAAPSPPDT MVMSMETLQQ LTSRDDLLSM AEKVRGLPAI
MRLYLTASLS LLLRNPPSSL YHSNVVEEIE RLAKSNGDDP HIQQVLQVVV NSTGSNKTDL
RALREFINWE RVLARLVSLQ LLTEEALRQG SHPETTGDKN LEVCVSLDWL ERTLASGLKV
//
