ID J7RWA8_KAZNA Unreviewed; 877 AA.
AC J7RWA8;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Peptidase M20 dimerisation domain-containing protein {ECO:0000259|Pfam:PF07687};
GN Name=KNAG0C01680 {ECO:0000313|EMBL:CCK69282.1};
GN OrderedLocusNames=KNAG_0C01680 {ECO:0000313|EMBL:CCK69282.1};
OS Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / KCTC
OS 17520 / NBRC 10181 / NCYC 3082 / Yp74L-3) (Yeast) (Saccharomyces
OS naganishii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071383 {ECO:0000313|EMBL:CCK69282.1, ECO:0000313|Proteomes:UP000006310};
RN [1] {ECO:0000313|EMBL:CCK69282.1, ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN [2] {ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Genome sequence of Kazachstania naganishii.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M20A family.
CC {ECO:0000256|ARBA:ARBA00006247}.
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DR EMBL; HE978316; CCK69282.1; -; Genomic_DNA.
DR AlphaFoldDB; J7RWA8; -.
DR STRING; 1071383.J7RWA8; -.
DR eggNOG; KOG2276; Eukaryota.
DR HOGENOM; CLU_008535_0_0_1; -.
DR OMA; HATVCVD; -.
DR OrthoDB; 177966at2759; -.
DR Proteomes; UP000006310; Chromosome 3.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006751; P:glutathione catabolic process; IEA:InterPro.
DR Gene3D; 3.30.70.360; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR017149; GSH_degradosome_Dug2.
DR InterPro; IPR002933; Peptidase_M20.
DR InterPro; IPR011650; Peptidase_M20_dimer.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR43270; BETA-ALA-HIS DIPEPTIDASE; 1.
DR PANTHER; PTHR43270:SF8; DI- AND TRIPEPTIDASE DUG2-RELATED; 1.
DR Pfam; PF07687; M20_dimer; 1.
DR Pfam; PF01546; Peptidase_M20; 1.
DR Pfam; PF00400; WD40; 1.
DR PIRSF; PIRSF037237; Peptidase_WD_repeats_DUG2; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006310};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 60..91
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 395..410
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 627..770
FT /note="Peptidase M20 dimerisation"
FT /evidence="ECO:0000259|Pfam:PF07687"
FT REGION 176..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 877 AA; 97643 MW; C3FD2D7C83544BA3 CRC64;
MLGRPELMHR WNHSHSILSI CVFPHKKLLF AGTQDSKILV LDKATYNIVE TLHLGESQDQ
ANTRSSVLCM DRSADERYLF SAGADSLVRV WFVDHCKANG SVVIKELATV YSVTDIGDIF
ALRYLEATQT LVFGCQNASL LFINNIIEKV SGNRPMDPQT NLDKLPHRRY DKFFDSLGPS
ESATPNPSTS DLTKNSREAS PPCNASTRVA STILEVPAEN IVRYAHNGFI YSICKLPHEI
NICNTDGALR DSEDRSVQES IISGSGDGVS KIWRFTKSDN GEVTIKLVAE EMDNDDVVFS
QTVEFPFLYC GLGDGAINIW DLNTRQLVSH LQTPTKSDVT SLTVYEDYVF AVIEEGITIF
YGDQISHWDP YQGKLLSSEV FESCSQTDNG GYPGLVAGGN DGSLTLWDLK DLFETAPSTT
NRMDFQRRSS WVTYKPPKID TEEMLSTLKR LIAFQTVSQG SDTAYQMASR KCATFLLGLF
KHFGAVDSQL LPAPNNCKSV VTAIQGKNPN NKRIVWYGHY DVIAPGDTDR WNTEPFNLTC
ENGYLKGRGV TDNKGPLVSA LYSVTTLLQQ DNLLNDVVFL VEGSEEIGSP GFESVCHKYK
HLIGDNIDWI LLSNSSWVDR EHPCLNYGLR GVVNAQLKIY SDQSNGHSGV NGGVYWEPTF
DLLKVVSNLR DAEGRIKIPG FYDSLTPTSE EDSERFKNIL EVTELVNNST LENVIDNWTR
PSLSVTAMGV SGSGNVTVIP KVAWMGVSIR IVPGQNLKTV KESFIKYVND CFEEIGSPNH
LRVTIMNEAE AWLGDPTNHA YQVAREEIYN AWQVEPLFVR EGGSIPSVRI LERVLDAPAV
QIPCGQSTDN AHLDNENLRI KNWTNLADIL ANVFNRL
//
