ID J7SAR8_KAZNA Unreviewed; 598 AA.
AC J7SAR8;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN Name=KNAG0M01110 {ECO:0000313|EMBL:CCK72964.1};
GN OrderedLocusNames=KNAG_0M01110 {ECO:0000313|EMBL:CCK72964.1};
OS Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / KCTC
OS 17520 / NBRC 10181 / NCYC 3082 / Yp74L-3) (Yeast) (Saccharomyces
OS naganishii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071383 {ECO:0000313|EMBL:CCK72964.1, ECO:0000313|Proteomes:UP000006310};
RN [1] {ECO:0000313|EMBL:CCK72964.1, ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN [2] {ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Genome sequence of Kazachstania naganishii.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR EMBL; HE978326; CCK72964.1; -; Genomic_DNA.
DR AlphaFoldDB; J7SAR8; -.
DR STRING; 1071383.J7SAR8; -.
DR eggNOG; KOG1116; Eukaryota.
DR HOGENOM; CLU_013399_0_2_1; -.
DR OMA; TTHRMHG; -.
DR OrthoDB; 374620at2759; -.
DR Proteomes; UP000006310; Chromosome 13.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017050; F:D-erythro-sphingosine kinase activity; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR InterPro; IPR045540; YegS/DAGK_C.
DR PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF19279; YegS_C; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006310};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 187..326
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 30..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 65984 MW; 3ED215CA9621D844 CRC64;
MSRFRLKPLP RAILTDDGVL IKSQNANPLS FHSNALRDPD AGPDDKGCDD GTHERGAGES
MFCLTCLSDS TNFDSNGRGI LPMNTVIPYG RIINAHNVRS LGATQTTKKS KQDTTISTAL
LANDDDGLSM DLENDAMDYV IDLVFVLPLE KNVVPRTVRL NIDYVPLSPA SSDLAEVILK
RSYKNARRNK KMLVIINPFG GKGQAKNLFF QRAAPILDAS GSDYDIAYTE RSRHAVEIAE
SLDIDKYDTI VCASGDGIPY EVLNGLYRRI DRVAAFNKIV VTQLPCGSGN AMSISCHWTM
NTSYAALCLL KSQESRIDVM CCQQPSYSDQ PRLSFLSQTY GIIAESDINT EFIRWMGPIR
FNIGVAFNLL QGKTYACDVY VKYAAKTKHD MKVHYLLHKK TAELIFDSPP ASSSSASLSQ
SNPLNEHLQS ASSSSLSTPP TPAQESVISS EDFNLKYSLS DPIPEEWERL SSDITDNLSI
FYTGKMPYIA DKTKFFPAAL PADGAIDLVI MNSTTSVRRM TPILLSLDDG THVMQPEVLH
SKVSAFRLVP HIEEGLISVD GEKFPLEPMQ VEVLPSLVKT LLRNGSYIDT EFDTLLST
//
