GenomeNet

Database: UniProt
Entry: J8LHV0_SACAR
LinkDB: J8LHV0_SACAR
Original site: J8LHV0_SACAR 
ID   J8LHV0_SACAR            Unreviewed;       840 AA.
AC   J8LHV0;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   05-JUL-2017, entry version 18.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=SU7_3355 {ECO:0000313|EMBL:EJS41592.1};
OS   Saccharomyces arboricola (strain H-6 / AS 2.3317 / CBS 10644) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=1160507 {ECO:0000313|EMBL:EJS41592.1, ECO:0000313|Proteomes:UP000006968};
RN   [1] {ECO:0000313|EMBL:EJS41592.1, ECO:0000313|Proteomes:UP000006968}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H-6 / AS 2.3317 / CBS 10644
RC   {ECO:0000313|Proteomes:UP000006968};
RX   PubMed=23368932; DOI=10.1186/1471-2164-14-69;
RA   Liti G., Nguyen Ba A.N., Blythe M., Mueller C.A., Bergstroem A.,
RA   Cubillos F.A., Dafhnis-Calas F., Khoshraftar S., Malla S., Mehta N.,
RA   Siow C.C., Warringer J., Moses A.M., Louis E.J., Nieduszynski C.A.;
RT   "High quality de novo sequencing and assembly of the Saccharomyces
RT   arboricolus genome.";
RL   BMC Genomics 14:69-69(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EJS41592.1}.
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DR   EMBL; ALIE01000186; EJS41592.1; -; Genomic_DNA.
DR   EnsemblFungi; EJS41592; EJS41592; SU7_3355.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000006968; Chromosome XV.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:EnsemblFungi.
DR   GO; GO:0016049; P:cell growth; IEA:EnsemblFungi.
DR   GO; GO:0043623; P:cellular protein complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0006797; P:polyphosphate metabolic process; IEA:EnsemblFungi.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006968};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006968};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    417    441       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    462    479       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    539    561       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    573    595       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    633    651       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    736    759       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    765    788       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   840 AA;  95525 MW;  BE47591EBBDF5E4E CRC64;
     MSEKEEAIFR SAEMALVQFY IPQEISRDSA YTLGQLGLVQ FRDLNSKVRS FQRTFVNEIR
     RLDNVERQYR YFYSLLKKHD IKLYEGDTDK YLDGTGELYV PPSGSVIDDY VRNASYLEER
     LIQMEDATDQ IELQKCDLEQ YRFILQSGDE FFLKGDNTSG TSYMDEDMID GNGENIRAAI
     GASVNYVTGV IAREKIATLE QILWRVLRGN LFFKTVEIDQ PVYDVKSKEY KQKSAFIIFS
     HGDLIIKRIR KIAESLDANL YEVDSSNDGR SQQLAKVNKS LSDLYTVLKT TSTTLESELY
     AIAKELDSWF QDVTREKSVF EILNKSNYDT NRKILIAEGW IPKDELATLQ ARLGEMITRL
     GIDVPSIIQV LDTNRTPPTF HRTNKFTSGF QNICDCYGIA QYREINAGLP TIVTFPFMFA
     IMFGDMGHGF IMFLAALALV LSEKKINKMK RGEIFDMAFS GRYIILLMGI FSMYTGFLYN
     DIFSKTMTIF KSGWKWPDHW KKGETITATA VGTYPIGLDW AWHGTENALL FSNSYKMKLS
     ILMGFIHMTY SYFFSLANHL YFNSMIDIIG NFIPGLLFMQ GIFGYLSVCI VYKWAVDWVK
     DGKAAPGLLN MLINMFLAPG TIDDELYPHQ AKVQVFLLLM ALVCIPWLLL VKPLHFKFTH
     KTKSHEALPS TDADASSEDL EAQQLITAMD ADDAEEEEVG SGSHGEDFGD IMIHQVIHTI
     EFCLNCVSHT ASYLRLWALS LAHAQLSSVL WTMTIQIAFG FRGFLGVFAT VALFAMWFAL
     TCAVLVLMEG TSAMLHSLRL HWVESMSKFF VGEGLPYEPF TFEYKDMEVA VANATSSAST
//
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