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Database: UniProt
Entry: J8VZR4_9SPHN
LinkDB: J8VZR4_9SPHN
Original site: J8VZR4_9SPHN 
ID   J8VZR4_9SPHN            Unreviewed;       478 AA.
AC   J8VZR4;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-SEP-2017, entry version 35.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EJU13528.1};
GN   ORFNames=LH128_08246 {ECO:0000313|EMBL:EJU13528.1};
OS   Sphingomonas sp. LH128.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=473781 {ECO:0000313|EMBL:EJU13528.1, ECO:0000313|Proteomes:UP000004402};
RN   [1] {ECO:0000313|EMBL:EJU13528.1, ECO:0000313|Proteomes:UP000004402}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LH128 {ECO:0000313|EMBL:EJU13528.1,
RC   ECO:0000313|Proteomes:UP000004402};
RX   PubMed=24657861; DOI=10.1128/AEM.00306-14;
RA   Fida T.T., Breugelmans P., Lavigne R., van der Meer J.R., De Mot R.,
RA   Vaysse P.J., Springael D.;
RT   "Identification of opsA, a Gene Involved in Solute Stress Mitigation
RT   and Survival in Soil, in the Polycyclic Aromatic Hydrocarbon-Degrading
RT   Bacterium Novosphingobium sp. Strain LH128.";
RL   Appl. Environ. Microbiol. 80:3350-3361(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EJU13528.1}.
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DR   EMBL; ALVC01000091; EJU13528.1; -; Genomic_DNA.
DR   RefSeq; WP_008829124.1; NZ_ALVC01000091.1.
DR   PATRIC; fig|473781.5.peg.1623; -.
DR   Proteomes; UP000004402; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004402};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004402}.
FT   DOMAIN      174    322       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      386    455       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     182    189       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   478 AA;  53084 MW;  4C32E59626B9AF9A CRC64;
     MEEDQEAVNL AADWADISQG LRKDLGHQAH SQWIKPIQPG NWCKETGTLD LYLPTEFSAN
     WVNDRFADRL SLAWKIARPD VRHVRILVHP GRRQLPELRL GGGGGRPASA PANDSAAGVA
     DPLSVALAGE SFASLGQGPA GIDASQTFTS FVTGTSNVLA CNAAQRMAAT EQPQFSPLYL
     KAATGQGKTH LLHAIGHAYL AAHPHARIFY CSAERFMVEF VQALRQNQMI EFKSRLRGFD
     LLLVDDIQFI IGKASAQEEL LYTIDALLQE GKRLVFAADR APQALDGVEP RLLSRLSMGL
     VADIQPADIE LRRSILENRL GRFASVEVPA DVIEFLARTI NRNVRELVGG LNKLIAYAQL
     TGQAVSLQLA EEQLTDILSA NRRRITIDEI QRTVCQFYRI DRTEMSSKRR ARAVVRPRQV
     AMYLAKVLTP RSYPEIGRKF GGRDHSTVIH AVRLIEELRT RDADMDGDVR SLLRQLES
//
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