ID J9B4N1_WUCBA Unreviewed; 556 AA.
AC J9B4N1;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Animal heme peroxidase {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=WUBG_07112 {ECO:0000313|EMBL:EJW81975.1};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW81975.1, ECO:0000313|Proteomes:UP000004810};
RN [1] {ECO:0000313|Proteomes:UP000004810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Wuchereria bancrofti.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJW81975.1}.
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DR EMBL; ADBV01003217; EJW81975.1; -; Genomic_DNA.
DR AlphaFoldDB; J9B4N1; -.
DR Proteomes; UP000004810; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR PANTHER; PTHR11475:SF144; NAD(P)H OXIDASE (H(2)O(2)-FORMING); 1.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 4: Predicted;
KW Heme {ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|PIRSR:PIRSR619791-2}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 499..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT BINDING 238
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
FT NON_TER 556
FT /evidence="ECO:0000313|EMBL:EJW81975.1"
SQ SEQUENCE 556 AA; 63743 MW; 2F334D3A31619623 CRC64;
MKKLVAGQVI AYEIMQSTLV SCPLEMHKIP VPRCDAIFDA QCMGKTEIPF VRAKYDKKTG
HGFNAPREQM NERTSWIDAS FLYSTQEPWV AALRAWNNGS LLEGPMKDYP PLNGPRIPLI
NPAPPQIHRL MNPERLFMLG DPRTNENPGL LSLGLILYRW HNIQAKRIQE EHPNWTDEEV
FQGARRWVIA TLQKITLYDF LPVMLADEKA IPPYEKYKPL VPPGISHAFA TAAFRFPHTI
VPPALLLRKR TNGKCEFRDE VGGYPALRLC QNWWNAQDIV QEYSVDEIVL GMASQIAEGE
DAVVVEDLRD FVFGPMHFTR LDVVSSSIMR GRDNGLPPYN ELRQSYNLPI RDWVTINPVM
YKEKPKIFHE LEKLYEGDIS KLDAYVGGML ETNGEGPGEL FRAIILDQFL RLRDGDRFWF
ENTWNGIFTK EEIKQIHSTT LRDIIRETTS IDEHELQENV FLWRAGDPCG QPFQVNTSGL
EPCIPFMRFD HFTGNEVTFI FSCIALGIIP LICIGIGYML IQKRKKLGGD MEPCLKKLFL
ESTNPSNTRS ELIKKN
//
