ID   J9DUB1_9PROT            Unreviewed;       516 AA.
AC   J9DUB1;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Deoxyribodipyrimidine photolyase {ECO:0000313|EMBL:EJW20572.1};
GN   ORFNames=IMCC14465_16970 {ECO:0000313|EMBL:EJW20572.1};
OS   alpha proteobacterium IMCC14465.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; PS1 clade.
OX   NCBI_TaxID=1220535 {ECO:0000313|EMBL:EJW20572.1, ECO:0000313|Proteomes:UP000004836};
RN   [1] {ECO:0000313|EMBL:EJW20572.1, ECO:0000313|Proteomes:UP000004836}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IMCC14465 {ECO:0000313|EMBL:EJW20572.1,
RC   ECO:0000313|Proteomes:UP000004836};
RX   PubMed=23209213; DOI=10.1128/JB.01888-12;
RA   Yang S.J., Kang I., Cho J.C.;
RT   "Genome Sequence of Strain IMCC14465, Isolated from the East Sea, Belonging
RT   to the PS1 Clade of Alphaproteobacteria.";
RL   J. Bacteriol. 194:6952-6953(2012).
CC   -!- COFACTOR:
CC       Name=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate;
CC         Xref=ChEBI:CHEBI:15636; Evidence={ECO:0000256|ARBA:ARBA00001932};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|PIRSR:PIRSR602081-1};
CC       Note=Binds 1 FAD per subunit. {ECO:0000256|PIRSR:PIRSR602081-1};
CC   -!- SIMILARITY: Belongs to the DNA photolyase family.
CC       {ECO:0000256|RuleBase:RU004182}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EJW20572.1}.
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DR   EMBL; ALYF01000008; EJW20572.1; -; Genomic_DNA.
DR   AlphaFoldDB; J9DUB1; -.
DR   STRING; 1220535.IMCC14465_16970; -.
DR   PATRIC; fig|1220535.3.peg.1689; -.
DR   eggNOG; COG0415; Bacteria.
DR   OrthoDB; 9772484at2; -.
DR   Proteomes; UP000004836; Unassembled WGS sequence.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.80; -; 1.
DR   Gene3D; 1.10.579.10; DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR   InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR   InterPro; IPR005101; Cryptochr/Photolyase_FAD-bd.
DR   InterPro; IPR002081; Cryptochrome/DNA_photolyase_1.
DR   InterPro; IPR006050; DNA_photolyase_N.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR11455; CRYPTOCHROME; 1.
DR   PANTHER; PTHR11455:SF9; CRYPTOCHROME-1; 1.
DR   Pfam; PF00875; DNA_photolyase; 1.
DR   Pfam; PF03441; FAD_binding_7; 1.
DR   PRINTS; PR00147; DNAPHOTLYASE.
DR   SUPFAM; SSF48173; Cryptochrome/photolyase FAD-binding domain; 1.
DR   SUPFAM; SSF52425; Cryptochrome/photolyase, N-terminal domain; 1.
DR   PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   Chromophore {ECO:0000256|RuleBase:RU004182};
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR602081-1};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630, ECO:0000256|PIRSR:PIRSR602081-
KW   1}; Lyase {ECO:0000313|EMBL:EJW20572.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004836}.
FT   DOMAIN          3..133
FT                   /note="Photolyase/cryptochrome alpha/beta"
FT                   /evidence="ECO:0000259|PROSITE:PS51645"
FT   BINDING         212
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
FT   BINDING         269
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602081-1"
SQ   SEQUENCE   516 AA;  59365 MW;  AF4E1C4AD5E58722 CRC64;
     MPKVDIVWFK RDLRVQDHAP LKAASMSGNG VLPLYVVEDD YWAQPFASER HWFFLETSLA
     ELRKDCASLG MPLIVRAGDV CAVLADLKQT FDLQAVYAHE ETGNGWTYER DKRVLRWCRD
     NNIQFNEFPS NGVVRRLANR DKWSLERNRR MAQDVVSVPN GIRPVDGIEL GIIPDVKHVF
     KNPQAVHEVQ QGGRKAGQGV VKSFVESRVS RYLTCLSAPG LSEQYASRLS PHLTWGTLSV
     KEVVKTLAHY KNKADPRELS ASRRSLSAFQ SRLSWRCHFI QKLEDQPSIE TSCMHKFFEG
     MREGEHNQAF YDAWKNGMTG YPFIDACMRN LNHNGWITFR MRAMLVSFAS YNLWLDWRKT
     GYHLAQVFTD YEPGIHYSQL QMQSGVTGIN TVRIYNPIKQ SMDHDSTGAF IRRWVPELQH
     VGSDWIHEPW KMDAAQQQKA QVKIGDSYPA PLNEHATAVK SARAKMADVF RREGFREDSK
     VVYDTLGSRR RQPKRTARTK KVKQAMQSKA QLSFFD
//