ID J9E1Z4_WUCBA Unreviewed; 331 AA.
AC J9E1Z4;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS01186};
DE Flags: Fragment;
GN ORFNames=WUBG_12932 {ECO:0000313|EMBL:EJW76158.1};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW76158.1, ECO:0000313|Proteomes:UP000004810};
RN [1] {ECO:0000313|Proteomes:UP000004810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Wuchereria bancrofti.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJW76158.1}.
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DR EMBL; ADBV01009485; EJW76158.1; -; Genomic_DNA.
DR AlphaFoldDB; J9E1Z4; -.
DR Proteomes; UP000004810; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 185..200
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT DISULFID 1..19
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 34..46
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 41..59
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 53..68
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 82..94
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 89..107
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EJW76158.1"
FT NON_TER 331
FT /evidence="ECO:0000313|EMBL:EJW76158.1"
SQ SEQUENCE 331 AA; 37723 MW; A0DBD12EE36CAFDE CRC64;
CANKHCIHAS WECDGDNDCL DGSDEHPNCT YSQCQSEFWQ CANNKCIPNS WKCDGNDDCD
DGSDEKDCTD KSASSSSITN SCPVGQFRCS SGECIAETKV CDRVYDCSDR SDESSKCFIN
ECTSAEKALC EQKCVDLPID YRCDCFDGFA LDKDDKKSCH DIDECETGLG QCSQKCENKI
GTYKCWCTDG YAISSDDRTC KRVSTDPEPW LLFANKHYIR KLTLDGENYE LVARGFENVI
SMDIDMKERK VYLVDSGKLR LYRVSMEELD QPIDSYEVVL RHNVFGTEGI AIDWIGRKLY
MLNRQERSLR VCELDGRYCR TLIRDRIAQP K
//
