ID J9ETR8_WUCBA Unreviewed; 266 AA.
AC J9ETR8;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=GPN-loop GTPase 2 {ECO:0000256|ARBA:ARBA00014588, ECO:0000256|RuleBase:RU365059};
GN ORFNames=WBA_LOCUS3880 {ECO:0000313|EMBL:VDM10494.1}, WUBG_03089
GN {ECO:0000313|EMBL:EJW86001.1};
OS Wuchereria bancrofti.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Wuchereria.
OX NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW86001.1, ECO:0000313|Proteomes:UP000004810};
RN [1] {ECO:0000313|Proteomes:UP000004810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heilman E.R., Heiman D., Hepburn T.,
RA Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M.,
RA Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S.,
RA Walk T., White J., Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Wuchereria bancrofti.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EJW86001.1}
RP NUCLEOTIDE SEQUENCE.
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R.,
RA Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B., Mehta T.,
RA Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Haas B.,
RA Henn M.R., Nusbaum C., Birren B.;
RT "The Genome Sequence of Wuchereria bancrofti.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:maker-PairedContig_824-snap-gene-0.7-mRNA-1}
RP IDENTIFICATION.
RC STRAIN=pt0022
RC {ECO:0000313|WBParaSite:maker-PairedContig_824-snap-gene-0.7-mRNA-1};
RG WormBaseParasite;
RL Submitted (NOV-2016) to UniProtKB.
RN [4] {ECO:0000313|EMBL:VDM10494.1, ECO:0000313|Proteomes:UP000270924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Small GTPase required for proper localization of RNA
CC polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC step prior to nuclear import. {ECO:0000256|ARBA:ARBA00003181,
CC ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR EMBL; ADBV01000909; EJW86001.1; -; Genomic_DNA.
DR EMBL; UYWW01001433; VDM10494.1; -; Genomic_DNA.
DR STRING; 6293.J9ETR8; -.
DR WBParaSite; maker-PairedContig_824-snap-gene-0.7-mRNA-1; maker-PairedContig_824-snap-gene-0.7-mRNA-1; maker-PairedContig_824-snap-gene-0.7.
DR OMA; ATHNYFL; -.
DR Proteomes; UP000004810; Unassembled WGS sequence.
DR Proteomes; UP000270924; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17871; GPN2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030231; Gpn2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF3; GPN-LOOP GTPASE 2; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059};
KW Reference proteome {ECO:0000313|Proteomes:UP000270924}.
SQ SEQUENCE 266 AA; 29902 MW; 6DD0E10CB7BE83E0 CRC64;
MMFGQIIIGA PGAGKTTYCD GMSQILSQLG RPVICVNLDP ANDYLPYKCD IDIRELVKVE
DITSRLNLGP NGALRYCMQT LKKNIEWLRL KLSRVDGYLL FDFPGQLELY NSDDCITSII
HSMEKWGLRL VAVHLSDSLY CSDAGKFISV LLSALSIMIN LECAQINVLS KQDLLSDNDL
PYNFEFFEQL PDALRLVELL DESPILKQYK GLNEMLCSVI GDYDLVKFTG LDVTSKKHML
NLLKLADTAN GYAFTEAPDL RNIVQQ
//
