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Database: UniProt
Entry: J9F392_WUCBA
LinkDB: J9F392_WUCBA
Original site: J9F392_WUCBA 
ID   J9F392_WUCBA            Unreviewed;       755 AA.
AC   J9F392;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   25-OCT-2017, entry version 15.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=WUBG_00108 {ECO:0000313|EMBL:EJW88988.1};
OS   Wuchereria bancrofti.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Spirurida;
OC   Filarioidea; Onchocercidae; Wuchereria.
OX   NCBI_TaxID=6293 {ECO:0000313|EMBL:EJW88988.1, ECO:0000313|Proteomes:UP000004810};
RN   [1] {ECO:0000313|Proteomes:UP000004810}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NA {ECO:0000313|Proteomes:UP000004810};
RA   Nutman T.B., Fink D.L., Russ C., Young S., Zeng Q., Koehrsen M.,
RA   Alvarado L., Berlin A., Chapman S.B., Chen Z., Freedman E.,
RA   Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA   Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B.,
RA   Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Wuchereria bancrofti.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EJW88988.1}.
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DR   EMBL; ADBV01000013; EJW88988.1; -; Genomic_DNA.
DR   InParanoid; J9F392; -.
DR   Proteomes; UP000004810; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 2.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004810};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004810};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    343    367       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    388    406       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    476    496       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    508    528       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    597    616       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       16     50       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   755 AA;  86288 MW;  6C24AAC476501A3D CRC64;
     MLDTGENPDA PQPKEMIDLE ATFDKLENEL QEVNQNEEML KKNFSELMEL KHILRKTQQF
     FEEAGAETIV PPNAPIGTGL PEQIVLQETE GIGIELSGAG VTGQMFANFG FVAGVIERER
     LPAFERLLWR ACRGNVFLRQ SEIAEPLIDS TTGDPIINTV FIIFFQGDQL KTRVKKICEG
     FRATLYPCPD TPQERREMSI GVMTRIEDLK TVLGQTQDHR HRVLVAASKN VRMWLTKVRK
     IKSIYHTLNL FNLDVTQKCL IAECWCPVAD LSRIQLALKR GTEESGSTVP SILNRMSGIT
     EAPPTFHRVN KFTRGFQNIV DAYGIASYRE INPAPYTMIT FPFIFAVMFG DCGHGLIMLL
     CALFFIYREK QLEAARINDE IFQTFFNGRY VIFLMGCFSV YTGFIYNDAY SKSFNLFGSS
     WRNIYADLSK YESEKELMLT PQWAYYNLSI GPYPIGVDPI WNLAESNKLN FLNSMKMKMS
     IIIGVAQMTF GVMLSYENYK YFGSRLDILY MFIPQMLFLG CIFIYLCLEI LFKWLLFSAK
     SGYVLGYEYP SSNCAPSLLI GFISMFMMKH RPSGFLDPEG NVYPQCYLNL WYPGQSFFET
     LFVLLAAACI PIMLFGKPYM QWKEFKERAT LGSSNLSVRA ESNGDDAHII HNDLSRSSTT
     HIEEKFDFAD VMVYQAIHTI EFALGCISHT ASYLRLWALS LAHALLMEGL SAFLHALRLH
     WVEFQSKFYK GLGYAFVPFS FDKILEEART AEENI
//
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