ID J9FWE5_9SPIT Unreviewed; 717 AA.
AC J9FWE5;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Translation initiation factor IF-2, chloroplastic {ECO:0000256|ARBA:ARBA00044105};
GN ORFNames=OXYTRI_20152 {ECO:0000313|EMBL:EJY82326.1};
OS Oxytricha trifallax.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata; Spirotrichea;
OC Stichotrichia; Sporadotrichida; Oxytrichidae; Oxytrichinae; Oxytricha.
OX NCBI_TaxID=1172189 {ECO:0000313|EMBL:EJY82326.1};
RN [1] {ECO:0000313|EMBL:EJY82326.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JRB310 {ECO:0000313|EMBL:EJY82326.1};
RX PubMed=23382650; DOI=10.1371/journal.pbio.1001473;
RA Swart E.C., Bracht J.R., Magrini V., Minx P., Chen X., Zhou Y.,
RA Khurana J.S., Goldman A.D., Nowacki M., Schotanus K., Jung S., Fulton R.S.,
RA Ly A., McGrath S., Haub K., Wiggins J.L., Storton D., Matese J.C.,
RA Parsons L., Chang W.J., Bowen M.S., Stover N.A., Jones T.A., Eddy S.R.,
RA Herrick G.A., Doak T.G., Wilson R.K., Mardis E.R., Landweber L.F.;
RT "The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome
RT with 16,000 Tiny Chromosomes.";
RL PLoS Biol. 11:E1001473-E1001473(2013).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EJY82326.1}.
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DR EMBL; AMCR01006011; EJY82326.1; -; Genomic_DNA.
DR AlphaFoldDB; J9FWE5; -.
DR EnsemblProtists; EJY82326; EJY82326; OXYTRI_20152.
DR OrthoDB; 169393at2759; -.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF5; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:EJY82326.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 55..223
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 717 AA; 81162 MW; B49B28BBC7F0AC0D CRC64;
MDSHEILKRI EIISNDTIID EFTDLPVELI ETLAVEYEKE VEIIKDDKAR AQFKERPPVI
TIMGHVDHGK TTLLDAFRHS QKVKEEYGDI TQAIGAFTFV TDSEHEITFI DTPGHEAFQN
LRLRGAKTTD MIILVISAIE SIQPQTIEVI QISQKLKIPV IVAINKIDRN SADPDAVMLD
LATYDMIAEE LGGDLVCVPI SAKQKTNLDL LEQKIVEVAH SRVDLMEDFG CRAQCYIIES
NFDEKSTQVT ATVLVKKGTL NQDDIFVCGP HEGKVRFMRN DQGKNVKSAY PGQAVHLAGF
KSFPEVGLPL YACKNHEEAQ FMANRIQTRR DKEEQMKLFD DQLASEGLDM KKKIKGLTRM
EKRKMYGGDK SIMYEKIGLV EESDIDKYRK KLGIKKNVTD LVSKDAEDVE DLVSEAAAVQ
MQGINSKTKH KGRQVKLKQF EQDEFKKILH NYQEEQKKRE AMSPVEQARY DQERQKLKEV
YRDEDVKHFP IMIKASQAGV LETLLKEAEK VVGTHNYRIN IIDYSVGPVT EGDMNTALQT
GAVIFGFDVP IAPVVSRTAE SIGVCVKQHR IIYKFLEDVE HFVYDANTKI QEESGKAFHV
EVVGTAAISQ LFKIKDPKAK GNKLLTVAGC KVHGGDIERK YKFRVVRNGK ILQDNIKLHS
MKKMQQDVTI VEKGHECGLC LDNFDGELLP GDEIEAYKEL EGKLIKFNSK PGIHQSY
//
