GenomeNet

Database: UniProt
Entry: J9HFN5_9ACTN
LinkDB: J9HFN5_9ACTN
Original site: J9HFN5_9ACTN 
ID   J9HFN5_9ACTN            Unreviewed;       468 AA.
AC   J9HFN5;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=A27L6_001100000110 {ECO:0000313|EMBL:EJX35687.1};
OS   actinobacterium SCGC AAA027-L06.
OC   Bacteria; Actinobacteria.
OX   NCBI_TaxID=913338 {ECO:0000313|EMBL:EJX35687.1, ECO:0000313|Proteomes:UP000006343};
RN   [1] {ECO:0000313|EMBL:EJX35687.1, ECO:0000313|Proteomes:UP000006343}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SCGC AAA027-L06 {ECO:0000313|EMBL:EJX35687.1,
RC   ECO:0000313|Proteomes:UP000006343};
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Han J., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Huntemann M.,
RA   Wei C.-L., Han J., Chen A., Kyrpides N., Mavrommatis K., Markowitz V.,
RA   Szeto E., Pagani I., Pati A., Garcia S.L., McMahon T., Srivastava A.,
RA   Grossart H.-P., Martinez M., Stepanauskas R., Sczyrba A., Warnecke F.,
RA   Woyke T.J.;
RT   "The standard draft genome of actinobacterium SCGC AAA027-L06.";
RL   Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EJX35687.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AJWB01000073; EJX35687.1; -; Genomic_DNA.
DR   EnsemblBacteria; EJX35687; EJX35687; A27L6_001100000110.
DR   PATRIC; fig|913338.3.peg.1020; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000006343; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006343};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006343}.
FT   DOMAIN      160    288       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      372    441       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     168    175       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   468 AA;  52242 MW;  5CC1724D0547597F CRC64;
     MATVAQVDLQ KLWDQVVSSV STPQYSAFLV RTKPLGLLPG EDGSNLLLSA PDLFTKDVLE
     TRLRSILTEE LSNQLGEKVN IAVTVTSDGK SESGEVEVEP SVVENFTEVK GGTGRNSTSL
     NNNESAQLNP RYIFETFVIG ASNRFAHAAA VAVAEAPAKA YNPLFIYGDS GLGKTHLLHA
     IGAYAKELYG STRVRYVSSE EFTNDFINSI RDDKASVFQK RYRDLDILLV DDIQFLENKE
     RTQEEFFHTF NTLYNANKQI VISSDRPPKQ LTTLEDRLRS RFEWGLITDI QPPELETRIA
     ILRKKAAQDK LNAPDDVLEY IASKISTNIR ELEGALIRVT AFASLNRQGV DLSLAEIVLK
     DLIPEEGGPE ITGPTIMAQT ASYFSLTVDD LCGTSRSRVL VNARQIAMYL CREMTELSLP
     KIGQAFGGRD HTTVMHADRK IRQLMAERRS IYNQVTELTN RIKQQSKK
//
DBGET integrated database retrieval system